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Dopamine-serotonin dysbalance and the relation to myoclonus and psychiatric co-morbidity in patients with dystonia

To investigate if jerks and psychiatric disorders in patients with dystonia are associated with a hyperdopaminergic/ hyposerotonergic system and whether reversal of a hyposerotonergic state has a therapeutic effect.

The effect of cholinergic enhancement on brain activation in Parkinson*s disease patients with visual hallucinations using fMRI.

To investigate cerebral activation patterns after administration of an AChE-I (rivastigmine), compared to activation after placebo, in PD patients with VH.Secondly, to investigate whether cerebral activation changes after rivastigmine correlates…

Freezing of gait in Parkinson's disease: in search of the underlying mechanism and the application of a new treatment option

To investigate whether impairments of shifting between response sets underlie motor freezing in PD and to investigate the efficacy and the neural mechanism by which MPH improves gait and cognition in PD patients with FOG.

Reward mechanisms, mood and motivational symptoms in Parkinson's disease: an experimental approach

The objective of this project is to study the role of dopaminergic mechanisms in apathy, mood and HDD in patients with PD. What is the involvement of the dopaminergic neurotransmitter system in motivation and reward processes in PD and the clinical…