21 results
To evaluate the safety of E2007 given as adjunctive, long-term treatment in patients with refractory partial onset seizures with or without secondary generalization that completed the E2007-A001-206 or the E2007-G000-208 studies (revised per…
The development of a valid and reliable test intended to measure functional motor activities in daily life of children with DCD.
The purpose of this study is to determine the effects of a strength training program on physical functioning in children with CP.
In the proposed experiment we expect to find a similar functional segregation within prefrontal and premotor cortical regions when a free choice option is introduced.
The primary objective of this test series will be to gain experience and provide long-term safety using a transcutaneous titanium port as an access port for gastrostomy (T-Port) in the context of Duodopa treatment of severely afflicted PD patients.
Is time prediction of a future event specifically disturbed, compared to spatial prediction, in PD and FA, when compared to age-matched control subjects? Do the 2 patient groups differ from each other?
The aim of this pilot study is to evaluate whether precise HDsEMG-guidance improves the therapeutic effect of BTXA. Because of its minor functional importance and focused endplate distribution, the extensor digitorum brevis (EDB) muscle is selected…
*Evaluate our current measurement procedure (*UX analysis report*), that objectively and accurately records the 3D movement of the UX, in healthy children to establish norm values, normal variation and reproducibility in children*Test whether the UX…
We aim to experimentally evoke FOG in patients walking on a motorised treadmill, using either expected or unexpected obstacles, or changes in visual feedback of gait
The objective of this study is to examine the consequences of the use of an SSRI in pregnancy for motor and cognitive development of the child, in the short and long term.
Track-HD is designed to relate phenotypic characteristics in as many modalities as can be measured (clinical, cognitive, quantitative motor, oculomotor, neuropsychiatric, imaging, laboratory) and genetic factors, in order to relate phenotypic…
To demonstrate the likelihood of the motor causes of drooling in PD: reduced swallowing frequency (akinesia), open mouth and mouth breathing (rigidity), reduced swallowing capacity (hypokinesia) and stooped posture.
More knowledge about the clinical aspects of the FMR2 gene mutation can complete the couseling. Carriers with the desire to start a family can take the chance on POF in consideration. The clinical symptoms of FXTAS can be differentiated from other…
Collecting normal values of I-123-FP-CIT uptake with SPECT in striatum relative to occipital cortex uptake in heathy volunteers
The aim of the study is to gain insight on the somatotopy of the subthalamic nucleus. The relation between the postion o fthe electrode in the STN, the parameter settings of the stimulator and the effectiveness of the stimulation on Parkinson's…
To measure in vivo effect on neuroinflammation of treatment with celecoxib, a selective COX-2 inhibitor, in PD using PK111-95 and PET.Celecoxib showed broad utility in animal models of neurodegeneration. Neurochemical effect of the treatment on…
The objective of this project is to study the role of dopaminergic mechanisms in apathy, mood and HDD in patients with PD. What is the involvement of the dopaminergic neurotransmitter system in motivation and reward processes in PD and the clinical…
The design of an ambulant system that is capable of long-term estimation of the right UPDRS-levels for tremor, bradykinesia, and akinesia in patients with Parkinson*s disease receiving deep brain stimulation in the subthalamic nucleus using a…
The objective of this study is to acquire more insight into the capacity to carry out complex walking tasks in order to learn to understand what the underlying mechanisms of stumbling and falling in these children are.
identification of the needs of families with juvenile Huntington's disease