23 results
In this study we aim to examine the relationship between certain potential risk factors and the development of Parkinson Disease: environmental exposure to pesticides, exposure to extremely low frequency electromagnetic fields, and the role of…
The aim of the study is to evaluate the effectiveness of an activity stimulation program on performance of mobility and lifestyle in children with cerebral palsy, in comparison with regular paediatric physiotherapy.
1) To evaluate the efficacy of knee-ankle-foot orthoses (worn by night) in preventing a decrease of range of motion to ankle dorsiflexion in children with cerebral palsy (Clinical part). 2) To evaluate the effect of night-worn knee-ankle-foot…
- To investigate whether the effect of early-start rasagiline treatment (according to the ADAGIO study protocol) provided long term benefits over delayed-start.- To investigate the long-term effects of rasagiline in PD subjects who participated in…
Primary• To assess the efficacy of a fixed dose of pregabalin to placebo during the first12-week treatment period in subjects with RLS.• To compare the rate of augmentation of a fixed dose of pregabalin to 2 fixed doses ofpramipexole over 9 or 12…
Databases with multimodal brain imaging data (FDG-PET, VBM, DTI) will be created. From these data image features and network patterns will be extracted, to be used to create a supervised classification method for associating brain patterns to…
The aim of this study is to determine objectively and quantitatively the relationship between different stimulation settings, in different nuclei (the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi)) and the degree of…
The main goal of the proposed experiment is to provide evidence for the hypothesis that the adaptation range of posture control behaviour with only proprioceptive feedback is similar to the adaptation range with visual and tactile feedback also…
To investigate cerebral activation patterns after administration of an AChE-I (rivastigmine), compared to activation after placebo, in PD patients with VH.Secondly, to investigate whether cerebral activation changes after rivastigmine correlates…
Primary aim of the study is to evaluate the efficacy and safety of intramuscular magnesiumsulphate in CRPS I patients during 3 weeks dose escalation study.
In the present study, we investigate the role of the STN in different conditions.In earlier research, we found that the STN is involved in response selection and inhibition. This was investigated using behavioral measurements. Currently, we want to…
To investigate whether impairments of shifting between response sets underlie motor freezing in PD and to investigate the efficacy and the neural mechanism by which MPH improves gait and cognition in PD patients with FOG.
The objective of the study is to investigate the changes in cortical connectivity patterns, as measured by resting-state fMRI, as a consequence of the use of transcranial direct current stimulation.
To include Dutch subjects in a Canadian study to establish the frequency of intergenerational CAG size changes for individuals with an intermediate allele (27-35 CAG) for Huntington disease. This will allow us to understand the evolution of HD…
The primary objective of this study is to analyze the frequency and severity of fatigue in patients with spinocerebellar ataxia and to test whether duration of the disease, depression and the severity of ataxia are related to the severity of fatigue…
1. To determine whether AFO stiffness can be optimized for individual patients in terms of minimizing the energy cost of walking. 2. To asses whether the optimal AFO in terms of energy cost of walking matches the AFO at which the most energy can be…
The primary objective is to evaluate the effectiveness of occupational therapy in improving daily functioning of patients with Parkinson's Disease and reducing caregivers* burden.
To investigate the effects of galantamine on cognitive impairment and visual hallucinations in Parkinson`s disease, both therapeutic (direct effect) and preventive (protection against an acute increase of dopaminergic medication used by the patient…
Objectives: To optimize SSEP recording methods to improve diagnostic procedures in myoclonic disorders. More precisely, to determine whether enhanced N35 potentials are more commonly found using multichannel (64 channels) SSEP versus conventional (5…
The overall aim of the proposed research project is to investigate the therapeutic potential of mental practice embedded in daily therapy on the improvement in daily activities of adult patients with Parkinson*s disease and stroke patients. In the…