26 results
The primary objective of TRIHEP 3 is to evaluate the efficacy of triheptanoin in (i) increasing the short term energy response in the metabolic profile of the brain of early affected HD patients, as captured by 31P-MRS, and (ii) slowing atrophy in…
The overall objective of this study is to develop patient friendly and unobtrusive techniques to characterize motor function. In this context we will use video cameras combined with depth sensors (RGB-D sensors, such as Microsoft KinectTM) and…
Primary Objective: The primary objective of this study is to evaluate safety and tolerability of pridopidine in patients with HD.Secondary Objectives: The secondary objectives of the study are to assess the effects of long-term, open-label dosing…
The purpose of the study is to investigate how quickly and to what extent UCB0599 and UCB2713 are absorbed, distributed, metabolized (broken down) and excreted from the body (this is called pharmacokinetics). Since UCB0599 and UCB2713 will be…
We aim to extend our recent work on fundamental mechanisms that underlie automatic influences of reward on attention to clinical populations that suffer from reduced and excessive reward-driven behaviours. That is, we will investigate whether…
The primary objective of this pilot study is to determine the effectiveness of four treatment options for local skin reactions induced by continuous subcutaneous apomorphine infusion, as compared to no treatment.The primary endpoint is the measured…
Objective:The aim of this project is to apply motor-cognitive-mental elements together for psychiatric diagnosis, treatment, and prevention. We will examine and quantify the diagnostic value of motor-cognitive-mental elements in predicting (a)…
To understand the interrelations between muscle related parameters (muscle mass, muscle strength, physical performance), energy expenditure (actual physical activity and basal metabolic rate), and nutritional status (energy intake and protein status…
Main objectiveTo investigate whether dopamine affects the ability to initiate the correct step in response to a sudden change (improbable picture in a predictable context) in PD with and without FOG. Secondary objectiveTo investigate whether…
To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side effects in particular psychiatric and or cognitive symptoms.
1) to identify the effect of manipulating the electrical synapses in the IO on motor learning in healthy individuals during cerebellar specific motor adaptation tasks. 2) to identify the effect of manipulating the subthreshold oscillations in the IO…
To assess the feasibility and burden of the 24-hAIpHM to precisely measure saliva swallowing frequency during everyday life in PD patients.
Determine the efficacy of atDCS as compared to ctDCS and sham stimulation in the improvement of executive functioning in PD-MCI.
The main objective of this study is to assess the effect of visual cues (provided by smart glasses) in the form of visual lines on the floor on walking performance and occurrence of FOG in comparison to walking without visual cues and walking with…
The study will include a total of 250 physiotherapists and 1000 patients. The aims of this study are: (1) to perform *big data* analyses on the raw sensor data, in relation to concurrently acquired clinical data in these patients (limited version of…
Test whether aDBS is superior to continuous DBS (cDBS) in terms of effectiveness, side-effects and energy consumption in patients with Parkinson*s disease (PD) and dystonia.
Determine the reliability, validity and the sensitivity to change of the MYOTON Handheld Digital Palpation Device for measuring the severity of paratonia in patients with dementia and paratonia .Research questions are:(1) What is the validity of the…
The purpose of the study is to investigate how quickly and to what extent radiprodil is absorbed and eliminated from the body (this is called pharmacokinetics). It will also be investigated to what extent radiprodil is tolerated. In addition, 2 new…
The aim of this study is to explore whether subjectively experienced SB can be objectively assessed using computerized vision based analysis of motor performance upon awakening. Secondarily, patient experiences and data quality of the assessment…
Our objective is to investigate how individual finger movements are controlled within a sequential task. To study the presence and changes over time of motor overflow, multi-channel EMG on both intrinsic and extrinsic hand muscles are used. Changes…