21 results
The aim of this study is to determine NET availability in patients with neurodegenerative diseases to characterize NA system degeneration in people with Alzheimer's disease, Parkinson's disease (with and without dementia) and with…
The primary objective of this research is to determine the prevalence and magnitude of loss of benefit from DBS stimulation in patients who underwent DBS surgery for upper extremity tremor that was refractory to medical management. The secondary…
The primary objectives of this study are to assess the safety and estimate the radiation dose of the radioligand [18F]FB610, and to assess the optimal kinetic model for quantification of the tracer uptake. Secondary objectives are to determine…
This study has been transitioned to CTIS with ID 2023-505645-12-00 check the CTIS register for the current data. Main objective: To evaluate the efficacy of BIIB122 225 mg compared with placebo.Secondary objective: To evaluate the efficacy, safety…
Primary Objective: Determining the prevalence in advanced-stage PD patients of increased bacterial TDC activity in faeces and the prevalence of increased AADC activity in serum.Secondary Objectives:- Correlating TDC activity and AADC activity to…
Primary aim:Our primary aim is to repeat our previous pilot study (REMPET2) in a larger cohort of patients; i.e. to measure PDRP expression in approximately 159 iRBD patients at two-time points, with an approximate interval of four years. This data…
The primary objective of this clinical feasibility study in people with PD is to evaluate the feasibility and potential efficacy of home-based gamified AR gait-and-balance exercises with Cue X. Secondary objectives of this study are to validate the…
Primary:To evaluate the effects of pirepemat on falls frequency as compared to placebo.Secundary:To evaluate the effects of pirepemat on Parkinson's disease motor symptoms as compared to placebo.To evaluate the effects of pirepemat on apathy as…
To determine early and subtle MRI changes in premanifest and early manifest HD patients which distinguish them from the healthy population. This includes both structural/quantitative MRI data and MRI-signs of blood-brain barrier (BBB) breakdown. And…
The aim of this study is two-fold:1.To elucidate the role of neuroinflammation in FTLD2.To identify biomarkers to predict and monitor disease progression in FTLD3.To differentiate FTLD-TDP from FTLD-tau during life using biomarkers for…
To explore the safety and feasibility of continuous and intermittent hypoxia therapy in PD and the differences of symptom modification of different hypoxia protocols. Secondary outcomes include exploring the responsiveness of subjective and…
The primary objective is to determine the diagnostic accuracy of the automated diagnostic software (mPDia, Heuron) using SMWI to distinguish neurodegenerative parkinsonism from patients with non-neurodegenerative parkinsonism compared with the final…
In this study we will investigate how quickly and to what extent carbidopa and levodopa are absorbed, transported, and eliminated from the body when administered as the study compound, the CLE-600 oral system. We will also investigate the safety and…
This study has been transitioned to CTIS with ID 2023-510317-26-00 check the CTIS register for the current data. To evaluate the efficacy of PTC857 in reducing disease progression in subjects with amyotrophic lateral sclerosis (ALS)
This study aims to achieve 4 goals: (1) to identify the brain network involved in mediating the effects of cueing as an important compensation strategy; (2) to identify differences in brain connectivity patterns elicited by internal versus external…
Improving the clinical effect and efficiency of DBS for PD by investigating patient specific patterns of neuronal cell activity in the brain that are associated with symptom-severity. This may improve the clinical effect of DBS, and also result in…
Primary objective:- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dtuch SCA7 mutation carriers.Secondary objectives:- To quantify the annual change in disease-relevant clinical scales and…
Identify and evaluate digital parameters of fatigue and sleep that reflect daily self-reported measures in a mixed disease patient population.
To assess the efficacy and tolerability of HUTS with different angles, leading to optimal implementation strategies of HUTS to alleviate the impact of orthostatic hypotension and supine hypertension in PD
1. study the effects of an 8-week high-intensity interval training on motor and non-motor aspects (primary outcome: anxiety and depression) of Parkinson's disease and Multiple Sclerosis, compared to traditional continuous aerobic training and…