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A four-arm randomised, double-blind, placebo-controlled, multicentre Phase II study to evaluate the safety, tolerability and efficacy as assessed by frequent MRI measures of three doses of atacicept monotherapy in subjects with relapsing multiple sclerosis (RMS) over a 36 weeks treatment course.

Primary Objective: • The primary objective of the study is to evaluate the efficacy of three doses of atacicept to reduce CNS inflammation in subjects with RMS as assessed by frequent MRI.Secondary Objectives: • Evaluate safety and tolerability of…

Inventarisation of cognitive complaints and impairments in patients with multiple sclerosis

The primary objective of this study is to determine the prevalence and degree of cognitive complaints and impairment of patients with MS. Secondly we want to determine the relationship between age, gender, clinical type of MS and disease progression…

Feasibility and effectiveness of web-based cognitive behavioral therapy for multiple sclerosis patients with co-morbid depression: a pilot study.

The goal of this research project is to evaluate feasibility and outcome of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a comorbid depressive disorder.

Sirolimus (Rapamune®) for the treatment of anti-Hu associated paraneoplastic neurological syndromes

The primary objective of the trial is to study the efficacccy of sirolimus in paraneoplastisch neurological syndromes associated with anti-Hu antibodies (Hu-PNS)Secondary objectives are to correlate clinical improvement with anti-Hu antibody titers…

Vitamin D status and the T cell compartment in Multiple Sclerosis

The purpose of this study is to investigate the association between T cell compartment composition and vitamin D status in MS patients, with particular interest for regulatory T cell functionality.

A Two-Stage Phase 1 Repeat Dose Study of BaroFeron* (Recombinant Human Interferon beta-1b) Compared to Betaferon® for Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Subcutaneous Administration in Healthy Volunteers

Study Stage 1:To evaluate the safety and tolerability of BaroFeron administered subcutaneously (SC)To determine the PK and PD profiles of BaroFeron administered SC and compare to Betaferon administered SCTo evaluate evidence of activity of BaroFeron…