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Patient Reported Outcomes while Manipulating the Immune System in autoimmune Encephalitis

1. To measure clinical outcome of patients with an autoimmune encephalitis longitudinally.2. To evaluate existing PROMS, developed for other (neurological) disease, for patients with an autoimmune encephalitis.3. To develop and validate disease-…

Neural processing of olfactory stimuli in response to smell loss

The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…

Neuroinflammation and post-infectious fatigue in individuals with and without Covid-19

The aim of this study is to quantify neuroinflammation and whole-body inflammation with [18F]DPA-714 PET scans in post-COVID-19 patients and relate it to cognitive, psychiatric and post-infectious fatigue symptoms.

Pituitary Gland Stimulation for pain relief

To establish if targeted pituitary stimulation results in pain relief in cancer patients with opioid refractive pain or intolerance to opioids and patients with severe central neuropathic pain.

Open-label Uncontrolled Trial to Evaluate Pharmacokinetics, Pharmacodynamics, Safety, and Activity of Efgartigimod in Children From 2 to Less Than 18 Years of Age With Generalized Myasthenia Gravis

This study has been transitioned to CTIS with ID 2024-513854-31-00 check the CTIS register for the current data. To confirm an age-adjusted optimum dose of efgartigimod IV and provide (model-predicted) evidence for a treatment response.

Morphology of olfaction-related brain regions and brain functionality in response to odor exposure in healthy participants

To investigate brain morphology and brain activation in response to odor stimulation in participants with a normal smelling ability.