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Investigating pathophysiological mechanisms underlying ME/CFS and post-COVID symptoms in a paediatric population

The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…

Evaluating the effects of intravenous LPS in healthy male volunteers on (neuro)inflammatory biomarkers in CSF and blood

Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…