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Depression in Multiple Sclerosis: The effectiveness of web-based self-help treatment

The goal of this research project is to evaluate effectiveness of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a co-morbid depressive symptoms. With the online guided…

Test-Retest of MR Fingerprinting technology for improved visualization and quantification of tissue and organs in healthy volunteers and brain tumor patients

To optimise, test and evaluate new and modified MRI sequences and technology under a test-retest scheme. To validate new sequences in patients in order to reduce MRI protocols in the future.

Predictors of employment status and work absenteeism in relapsing-remitting Multiple Sclerosis

The main aim of this study is to examine predictors of (changes in) employment status and work absenteeism in relapsing-remitting MS patients and subjects without a chronic disease over a period of three years

Plegridy* (peginterferon β-1a) Real World Effectiveness and Safety Observational Program (POP)

This study will be conducted as a prospective, observational study of patients with relapsing forms of MS initiating treatment with Plegridy in routine clinical practice and patients who participated in Study 105MS302 or Study 105MS303. Enrolled…

A Double-masked, Placebo-controlled Study with Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders.

Primary Objective: To compare the efficacy of MEDI-551 versus placebo in reducing the risk of an NMO/NMOSD attack in subjects with NMO/NMOSD.Secondary Objectives:1. To compare the efficacy of MEDI-551 versus placebo on the reduction of EDSS…

A single-center randomized, adaptive, investigator/participant blind, single oral ascending dose, placebo-controlled Phase I study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of RO7189752 in healthy male participants.

The purpose of this study is to investigate how safe the new compound RO7189752 is and how well it is tolerated when it is administered as a drink to healthy male volunteers. RO7189752 has not been administered to humans before. It has been…

Study on Sophia HIV infected Children Cohort

1. Evaluation of neurocgnitive functioning in children with HIV in comparison with healthy siblings using questionnaires.2. Qualitative analysis of different determinants that play a role in school participation in children with HIV using interviews…

Prednisolone addition for patients with recent onset psychotic disorder: the role of immune-modulating strategies in the treatment of psychosis.

We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…