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Learning, Memory and Networks in the Human Brain: Single Neuron Recordings in Depth-electrode Candidates for Epilepsy Surgery

The first goal of the present study is to elucidate the network topology of the MTL on both large-scale and micro-scale levels with the aim of further understanding epilepsy related changes to the network structure. Additionally we will also use the…

MEG language and memory mapping: a comparison with WADA

Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch…

Clinical and molecular genetic aspects of idiopathic epilepsies

(1) Identification of novel loci and genes in which mutations are responsible for the development of inherited epileptic syndromes. (2) Establishing genotype-phenotype correlations; defining the yield of mutation screenings in specific patient…

Assessment of blood-brain barrier passage of flumazenil in pharmacoresistant patients with temporal lobe epilepsy

(1) To asses the influence of P-gp function at the BBB on flumazenil binding to the GABAA-receptor in pharmacoresistant patients with temporal lobe epilepsy (TLE), using PET and [11C]flumazenil as a ligand and tariquidar as P-gp blocker. (2) If we…

A pilot study on the use of Ketocal Infant in administering the ketogenic diet

Evaluation of tolerance to Ketocal Infant as measured by intake and effect on GI symptoms.To show that the growth of infants using Ketocal Infant is acceptable compared to infants with epilepsy.To evaluate teh ability of Ketocal Infant to attain an…

Prevalence of low bone mineral density in residents of a long-term facility care centre for people with refractory epilepsy, intellectual disability and long-term use of anti-epileptic drugs: a cross-sectional cohort study.

The main objective of this study is to determine the prevalence of low BMD measured with dual-energy X-ray absorptiometry (DEXA) and quantitative ultrasonography (QUS) in Providentia (a residential care facility for persons with refractory epilepsy…

Circadian Rhythm in Anti-Epileptic Drugs

Does adjustment of medication intake time to the individual circadian rhythm improve effects of AEDs?

Visual field analysis and diffusion tensor imaging after temporal lobectomy to map the functional anatomy of the anterior optic radiations

The main goal of this study is to map the functional anatomy of the anterior optic radiations by correlating the visual field defects to the surgical defects in Meyer*s loop in epilepsy patients after temporal lobectomy.

Lesional epilepsy: the effects of surgical intervention on ictal onset zone and permissive neural networks

The primary objective of this study is to characterize functional brain networks in patients considered for (i) epilepsy surgery and (ii) tumour surgery with epilepsy surgery techniques. Characterization will be done preoperatively (MEG), during…

IMAGINE-study (imaging study in epilepsy).
Is there a neuronal correlate for cognitive impairment and response to antiepileptic drugs in children with frontal lobe epilepsy?

In this study we investigate correlations between cognitive impairment as well as response to AED treatment in children with FLE and brain microstructure, function and neuronal connectivity, by using DTI, task related fMRI, and resting state fMRI.