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The relationship between pain and cognitive functioning, of patients with neurodegenerative diseases such as Parkinson's disease, Multiple Sclerosis and Huntington's disease
Substudy: The relationship between pain, cognitive functioning, and motor activity in patients with multiple sclerosis

Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…

Validation of a repeated cardiopulmonary exercise test for the assessment of physical impairment in chronic fatigue syndrome.

We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…

*A Randomized, Double-Blind, Placebo-Controlled Study to Determine Safety and Tolerability of LX6171 Oral Suspension Dosed for 28 Days in Subjects Exhibiting Age Associated Memory Impairment (AAMI) with a Lead-in, Open-Label, Single-Dose Relative Bioavailability Study of LX6171 Oral Suspension in Healthy Elderly Subjects*

Stage AThe primary objective is:• To compare the relative bioavailability of a single dose of 300 mg LX6171 using a 40mg/mL and an 80mg/mL formulated suspension;• To evaluate plasma concentrations of LX6171 and its major metabolite LP-523122 after a…

Evaluation of EmBlocker*

To study the efficacy of the EmBlocker* in heart operations. The EmBlocker* is placed in the thorax cavity and will reroute by the use of ultrasound the emboli in the aorta curve to the aorta descendens, in order to reduce the amount of emboli in…

Cerebrovascular dysfunction in Alzheimer and mild cognitive impairment.

Our working hypothesis is based on the interplay between vascular dysregulation, neuropathological alterations and decline in AD brain function. In the latent phase vascular dysregulation is already apparent when patients are asymptomatic.…

A multi-center, double-blind, parallel-group, placebo-controlled, randomized study: evaluation of the efficacy and safety of brivaracetam in subjects (16 to 70 years old) with Partial Onset Seizures.

To evaluate the efficacy of BRV at the doses of 20, 50 and 100 mg/day in b.i.d. administration in reducing seizure frequency in subjects with partial onset seizures not fully controlled despite optimal treatment with 1 to 2 concomitant AED(s),…

PROgnosis in Post Anoxic Coma II: PROPAC II

1) determine the level of NSE with a 100% certain predictive value for poor outcome in patients treated with hypothermia after CPR; 2) investigate relationships between SSEP during and after hypothermia; 3) Confirm the results of the PROPAC study,…

Brain activity during mental and physical tasks in stroke patients

The main aim of the study is therefore to examine mu wave activity during observation, execution of movements and during movement imagery in comparison to a passive resting state and active relaxation condition in stroke patients and matched healthy…

Apathy in patients with Parkinson*s disease and major depressive disorder, a structural brain imaging study using Voxel Based Morphometry

Primary objective: the primary objective of the present study is to assess whether apathy can be linked to structural brain changes (both atrophy of grey matter, as well as changes in white matter), whether apathy in PD is related to certain…

Pharmacokinetics of levetiracetam after rectal administration in healthy volunteers

Comparison of single-dose pharmacokinetics of levetiracetam after rectal versus oral administration at healthy volunteers.