21 results
The aim of this study is to analyse the analgetic effect of a local injection in the lateral femoral cutaneous nerve ( LFCN) with methylprednisolone/lidocaine (M/L) after localisation through elektro stimulation VS placebo. In this trial we hope to…
To study whether hyqvia is as effective, safe and tolerable (or more tolerable) as IVIg.
De lnternational CIDP Outcome Study (ICOS) aims to describe in detail the variation in clinical and electrophysiological subtypes, current practice of treatment, clinical course and outcom in CIDP. The second objective is to define the clinical and…
Primary clinical investigation objectives[Safety]The primary safety objective of the clinical investigation is to provide data that demonstrates safety of the device, defined as < 8.3% serious adverse device effects, up to 6 weeks following…
In this research project we explore anti-nociception as a state of pain modulation. Our main objectives in utilizing the plasticity of the central pain pathways are to: (i) Shift individuals from a pro-nociceptive pain modulation profile to an anti-…
The primary objective of this study is to investigate attenuation of pain and sensory thresholds during dorsal root ganglion stimulation using QST. The secondary objectives of this study are to investigate 1) To assess changes in pain intensity (NRS…
The aim of this study is to further explore ultrasonographic abnormalities of peripheral nerves in patients with NF and their relation with symptoms, findings in neurological examination and electrophysiological characteristics.Primary objective:…
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
Primary Objective: to assess formally the responsiveness of a core set of measures derived from the previous CI-PeriNoms Study (Cavaletti, et al., 2013).Secondary objective: to test the responsiveness of the CIPN specific Rasch-built Overall…
We purpose to determine whether the international normative values are applicable in our center in 10 healthy participants. Furthermore, CCM will be introduced as additional diagnostic tool in patients with (possible) SFN.
Primary Objective: To study whether nocturnal symptoms of CTS depend on wrist position and, if so, on which position. Identifying which wrist position aggravates CTS could help design a more effective splint. Secondary Objective: To study whether…
Primary objective is to study the number of patients gaining at least 50% pain reduction within 8 weeks following PRF as compared to following a neurectomy. Pain intensity will be measured using numeric pain rating score (NPRS, 0-10) and Verbal…
Molecular genetic testing for SEPT9 mutations is clinically available, but is not of much added value, at least in the Netherlands because of the low prevalence of SEPT9 mutations observed in Dutch HNA patients. Objective 1: To identify with WES de…
This mapping study will contribute to our understanding of the pathogenesis of ACNES and the complex anatomical distribution of sensory input of the trunk. It will also pave the way for a better diagnostic work-up, allowing for better surgical…
This study aims to develop a prediction rule for PMPS one year after breast surgery based on neurophysiological, psychological, and clinical parameters. Based on this prediction, individualized perioperative management and postoperative revalidation…
To estimate the frequency/ prevalence of acute or active HEV infection in patients presenting with (sub)acute post-infectious and/or immune-mediated neurological illness like neuralgic amyotrophy, (idiopathic) Guillain Barre syndrome, idiopathic…
To assess if resting membrane potential or ion channel activity is abnormal in sensory axons of affected nerves in MMN patients.
To explore whether patients with SCN9A-associated SFN have an abnormal brain activation pattern on resting state fMRI and altered structural connectivity on DTI versus age- and gender-matched healthy controls. With this knowledge, objective pain…
Primary objective: To evaluate the efficacy of IVIg treatment (4 courses of treatment, 3 weeks apart) compared to placebo on pain alleviation. Secondary objectives: 1. Pain intensity, pain qualities, and other SFN related complaints, daily and…
Objectives: 1. The first objective is to determine the nature and spatial distribution of sonographic abnormalities in CIAP and in CIDP, MIDN and MMN. 2. On the basis of the findings in objective 1, we will define a standardized HRUS research…