Search for a trial

Prospective evaluation of the non-invasive ICP Headsense monitor in TBI patients undergoing invasive ICP monitoring

To compare the accuracy of HeadSense*s non-invasive ICP monitor with the readings from the invasive ICP monitor.

Role of genetic polymorphisms, inflammation and biomarkers in primary and secondary traumatic brain injury

Main objective is to find clinical, genetic, biochemical and immunological markers of primary and secondary traumatic brain injury with the highest precision in predicting outcome after severe traumatic brain injury. Secondary objective is to gain…

Effects of mannitol and hypertonic saline on cerebral oxygenation and metabolism in patients with posttraumatic intracranial hypertension.

Aim of this study is to compare the effects of mannitol and HS in equimolar concentrations on cerebral blood flow, cerebral oxygenation, metabolism and inflammation in patients with severe TBI.

Evaluation of venous hypertension in craniosynostosis

Primary Objective: To evaluate intracranial venous haemodynamics in single suture craniosynostosis, and to determine the effect of surgery.Secondary Objective: Provide insight in the relationship between venous haemodynamics and intracranial…

The effect of intravenous lidocaine to prevent intracranial pressure increase in endotracheal intubation assessed by optic nerve sheath diameter

Primary Objective: To investigate the effect on the distention of the ONSD while using lidocaine 1,5 mg/kg IV during endotracheal intubation versus placebo. Secondary Objectives: The secondary objective of this study is to investigate the effect…