172 results
To study the time needed for full recovery of carotid body response to hypoxia (ie. hypoxic ventilatory response, HVR) after full recovery of neuromuscular block with and without reversal with sugammadex
Main: To evaluate the efficacy of continuing SZC as part of the discharge medications, compared to SoC, in maintaining NK Secondary:To evaluate the effect of continuing SZC as part of the discharge medications, compared to SoC:1. in reducing the…
The objective is to investigate if there is a flow-dependent effect of HFNC on ventilation during an EBUS procedure under procedural sedation in patients with COPD gold class 3-4.
Primary objective: • To assess the pharmacokinetics of DOR in patients prior to and after BSSecondary objectives: • To assess the safety of DOR in patients prior to and after undergoing BS• To assess the viral response to DOR in patients prior to…
The primary objective is to research whether the oral contraceptive pill in adolescents has a negative effect on emotion regulation in the form of fear acquisition and extinction. The secondary objective is to research whether a disruptive effect of…
To assess the efficacy of SARS-CoV-2 vaccination by the incidence of COVID-19 in patients with chronic kidney disease stage G4-G5, on dialysis and patients after kidney transplantation who received SARS-CoV-2 vaccination
The aim of this comparative effectiveness research is to determine the effect of intake of aspirin before bedtime in comparison with aspirin on awakening in patients already using aspirin for secondary prevention of CVD. Our primary objective will…
Investigate whether a low-dose of hydrocortisone (cortisol) reduces neuropsychiatric symptoms in glioma, meningioma and brain metastasis patients who are perioperatively treated with a high dose of the synthetic glucocorticoid dexamethasone,…
Preliminary guidance on how to support these patients in clinical practice will be derived. Primary objective is the change in drug concentrations in plasma (therapeutic drug monitoring) (mg/L) of the psychotropic drug after bariatric surgery (at 1…
This study has been transitioned to CTIS with ID 2022-502630-71-00 check the CTIS register for the current data. Primary objective: To evaluate the comparative long-term safety of TAK-503 treatment (formerly known as SPD503) in children and…
Primary Objective: To determine the effect of sex hormones on bone marrow fat. and visceral fatSecondary Objective(s): * To determine the effect of sex hormones on visceral and liver fat.* To test whether DXA can be used to calculate the amount of…
The main objective of this trial will be to get a better insight in the influence of age and age-related changes by internal and external factors on vaccine-induced immune responses and gain knowledge on the trajectory of immune decline in older…
The purpose of this study is to evaluate and document the safety information, how effective and cost effective the DTM SCS stimulation system is and the standard pain treatment in patients with chronic, difficult to treat back pain who are not…
This study has been transitioned to CTIS with ID 2024-512040-28-01 check the CTIS register for the current data. To assess the incidence of post-TIPS OHE within the first three months after prophylactic administration of lactulose and rifaximin…
- Primary objective: To compare the efficacy of postoperative pain treatments with sublingual sufentanil micro-tablets versus intravenous patient controlled analgesia with morphine or epidural analgesia in patients following pancreaticoduodenectomy…
This study has been transitioned to CTIS with ID 2023-509408-13-00 check the CTIS register for the current data. - To monitor the safety and tolerability of binimetinib- To monitor the safety and tolerability of encorafenib
The primary objective is to assess antibody responses against the SARS-CoV-2 vaccines in blood of individuals of 50-93 years of age at several timepoints post vaccination and post booster vaccinations, with respect to age, co-morbidities and frailty…
To determine the efficacy of a short high-dose treatment of oral prednisolone for persistent loss of smell after COVID-19 infection in the long term (>12 weeks). ADD: determining the clinical course/natural recovery of loss of smell and taste…
This study has been transitioned to CTIS with ID 2024-518041-16-00 check the CTIS register for the current data. The goal of the studies is multiple:1. To describe the pharmacokinetics of intravenously administered fentanyl and sufentanil;2. To…
The objective of this study is to evaluate the analgesic effect of ESPB as add-on therapy to multimodal analgesia on early postoperative pain after lumbar spinal fusion surgery compared to placebo.