337 results
In this phase III non-inferiority trial, the aim is to evaluate whether metoclopramide and palonosetron prophylactic antiemetic treatment are non-inferior to dexamethasone with regard to its efficacy to prevent delayed CINV induced by non-AC based…
Development of (f)MRI tasks and scan protocols and to define the optimal parameters in preparation of a (f)MRI study
Hypotheses: - Ileal delivery of casein and/or sucrose induces stronger effects on satiation compared to placebo- Ileal delivery of casein induces stronger effects on satiation than ileal fat delivery- Ileal delivery of sucrose induces stronger…
Primary objective:- Collecting and setting up norm values for the Steep Ramp Test for healthy children and adolescents between 8 and 18 years (what is the maximal attained work rate (Wpeak) during the Steep Ramp Test in healthy children and…
In this study we want to apply heavy water labelling to investigate how ageing affects the dynamics of different leukocyte populations.The main objectives of this study are:(A) to get more insight in the dynamics of an ageing immune system, in order…
The primary objective of this randomized trial is to reduce the HbA1c levels by 10% through exercise training with or without oral anti-diabetic medication in patients with coronary artery disease (PCI or CABG in stable CAD, or post STEMI and post…
The primary objective of this trial is to determine whether different types of anaesthesia [regional versus general] given to infants undergoing inguinal hernia repair result in equivalent neurodevelopmental outcomes. Secondary objectives are to…
1. What is the effectiveness of MIP (MI-based pre-treatment) compared to UC (usual care) on the level of participation and treatment drop-out in patients with chronic non-specific musculoskeletal pain following pain rehabilitation?2. What is the…
The main objective of the separate studies of this study is the evaluation of grasping performance when electrotactile or vibrotactile feedback is provided compared to the non-feedback and only visual feedback situation. The main question to be…
Phase 1: Investigate a possible suppressing effect of prophylactic paracetamol use in adults on the response of the hepatitis B vaccination. Phase 2: Study the association between timing of the use of paracetamol during hepatitis B vaccination and…
The aim of the present study is:a) to monitor the development of arm-hand use in a broad range of stroke patients over time both during and after clinical rehabilitation;b) to assess the rate of improvement (or decline) in arm-hand use during and…
The primary objective of this study is to examine the beneficial effects of nutritional support on the resistance type exercise training-induced changes in body composition and muscle fiber characteristics in healthy young men.
Primary objectiveDoes administration of THC produce an increase in subcortical dopamine level of chronic cannabis users? Does this effect on dopamine modulate the link between spontaneous eye blink rate, performance on divergent and convergent…
RO5458640 is an investigational therapy being studied by Hoffmann La Roche, Inc. and the Dutch Cancer Institute for treating solid tumor cancers. This study is looking for approximately 100 subjects with advanced solid tumors.
To determine the incidence of chronic pain and to identify risk factors for the development of chronic musculoskeletal pain after trauma to the extremities of the musculoskeletal system. Other objectives are determination of the prevalence of acute…
This study is part of a larger program of in total 6 parts. This program was split in two sub programs and each of these sub programs consists of three parts. The current study originally comprised 3 parts and a fourt part is added.The purpose of…
Primary Objective: 1) To study impairment and developmental delay in social cognition (and related cognitive functions) caused by brain damage in patients treated for a brain tumour in childhood as compared to a reference group of chronically ill…
The objective of the study is to gain insight in the role of endogenous GLP-1 on food-stimuli related CNS satiety and reward responses and the alterations between lean and obese-T2DM individuals. Also, to gain information about treatment with a GLP-…
The primary objective of the METFORMIN study is to determine the efficacy of metformin in combination with lifestyle-intervention in obese children and adolescents with insulin resistance versus placebo with lifestyle-intervention. The secondary…
First, to explore relationships between immunological factors (cytokines and chemokines), psychological stress, and pain, controlled for infection. Second, to explore relationships between immunological factors (MBL), bacterial colonisation and…