277 results
The primary objective of this study is to investigate the quality and content of the MTT-EP model in response to electrocutaneous stimuli by determining stimulus-related and/or physiological-related components, before and after the occurrence of HFS…
To investigate if a high loading dose of 2 grams paracetamol has a beneficial effect on pain sensation or has an opioid-sparing effect in patients with pain in the Emergency Department
Primary objective: The primary goal of this research is to compare peri-implant hard tissue around implants placed using a modified drilling protocol, i.e. a reduced drilling speed without cooling and around implants inserted using a default…
The goal of this study is to gain insight into the eating behaviors of women with an eating disorder (ED) and comorbid autism spectrum disorder (ASD). By comparing this group to two other groups (women with an ED but without ASD and women with an…
The objective of this study is to evaluate the feasibility and to determine the preliminary effects on physical functioning, muscle function, body composition and postoperative recovery of a combined preoperative nutrition and exercise intervention…
Primary Objective: This study aims to analyze cycling gross efficiency, pedalling power symmetry, and hip, knee, ankle kinematics in adults with a transtibial amputation in different foot positions and seat heightsSecondary Objective(s): The second…
The current study investigates which brain areas are related to habituation of pain (using fMRI) and enables a direct coupling with concurrent EEG. We will test the hypothesis that activation of areas in the brain show changes over time as correlate…
The aim of this study is to investigate the effect of two distalisation techniques of a gastric bypass in revisional surgery with standardised limb lengths in total weight loss (TWL) and the need for treatment for protein calorie malnutrition (PCM…
Primary objective is to investigate the effectiveness of the KLIK Pijnmonitor in reducing clinically significant pain in children at home by comparing the proportion of clinically significant pain between the intervention group and the control group…
The primary objective of this study is to confirm that the dissolution profiles of a sugar-free and sugared lozenge containing CPC/benzocaine (1.4mg/10 mg) are comparable following a single dose in healthy adult subjects.The secondary objectives of…
Understanding the specific vs. generalized role of the prefrontal cortex for prosocial decision-making. In particular, we want to investigate whether the prefrontal cortex is recruited during the evaluation of the abstract cost-benefit ratio of one*…
Objective: Primary objective: To determine pharmacokinetic profiles of an esketamine oral thin film with 50 or 100 mg esketamine; Secondary objective: (1) To determine the pharmacodynamic profile of an esketamine oral thin film containing 50 or 100…
This study will compare the study compound Mentholatum 10% w/w Ibuprofen Gel to a similar product, which is already on the market in UK called Ibuleve Maximum Strength Gel. The purpose of the study is to compare these two gels in how quickly and to…
To investigate the effect of banded sleeve gastrectomy
Our main objective is to probe for the functional time-windows of the mid-portion of the left middle temporal gyrus (mMTG) during word comprehension and word production to determine whether the left mMTG is common to both language comprehension and…
To study the effects of in vitro culture conditions, such as different culture media or oxygen tension, on omic layers (i.e. genome, epigenome and transcriptome) of preimplantation human embryos and to relate this to chromosoom instability (CIN).
Primary Objective:The primary objective of this study is to establish the occurrence of neutralizing antibodies to SPK-GAA capsid in participants with LOPD on an enzyme replacement regimen. Secondary Objective:The secondary objectives of this study…
This study will evaluate the safety, tolerability, and pharmacokinetics of idasanutlin as a single agent and the safety, tolerability, pharmacokinetics, and preliminary efficacy of idasanutlin in combination with either chemotherapy or venetoclax in…
Our primary objective is to determine the effect of ICU-VR-F on symptoms of depression, anxiety and PTSD, and the health-related quality of life (HRQoL) in family members of ICU patients. The secondary objective is to determine the effect of ICU-VR-…