Search for a trial

An exploratory single-center, cross-sectional study for the characterisation of human variability in toxicodynamics: towards the development of quantitative adverse outcome pathways.

Primary:Part A:. Evaluate the toxicodynamic variability in an evenly distributed cohort of male and female healthy volunteers Part B:. Evaluate the toxicodynamic variability among age, sex and ethnic backgrounds Exploratory:. Correlation of flow…

An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination with Pembrolizumab Versus Chemotherapy in Subjects with Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma that Expresses HER2 (IHC 1+ and Greater)

Primary Objectives:Associated pharmaceutical trial:To compare the efficacy of disitamab vedotin in combination with pembrolizumab to chemotherapy as first-line treatment in subjects with advanced UC that expresses HER2Clinical performance study:To…

Luminal Fructose Kinetics

To elucidate host/microbial intestinal (postprandial) fructose kinetics (by 13C incorporation in glucose and ethanol as well as other metabolites) in small intestinal fluid as well as plasma, urine and breath samples (whole body metabolism) and…

Joining forces to develop and evaluate a toolkit to promote sustained lifestyle change among overweight and obese multimorbid individuals with a combination of the chronic diseases type 2 diabetes mellitus, cardiovascular disease, and/or cancer: the Lifestyle medicine for individuals with multiple chronic diseases (LifeMeds) study

Objective 1. To conduct an extensive needs assessment on how to promote individually tailored (sustained) lifestyle changes in individuals with multimorbidity, including vulnerable groups and ethnic minorities.Objective 1.1: To gain in-depth…

Neutrophil and macrophage extracellular trap formation

-To investigate the development of ETs through the role of platelets and activated endothelium by performing co-culture experiments with neutrophils, macrophages, platelets and renal-derived endothelial cells. -To determine whether deceased donor…

Biasing decision flexibility with thalamic ultrasound stimulation

Our primary objective is to elucidate the neural and cognitive effects of short-term TUS to two thalamic subdivisions in humans. To this end, we target two thalamic subregions that are spatially adjacent yet feature divergent connectivity profiles…

TriaL to investigAte imMune checkpoint inhibitor related siccA syndrome

The primary objective is to determine the incidence and severity of sicca complaints after ICI administration. The secondary objectives are: 1) to measure changes in objective measures of oral and ocular dryness after ICI administration; 2) to…

PARC Healthcare Survey

To introduce human biomonitoring as a novel approach to study both exposure and as early indicators of effects related to the use of chemicals in hospital-based healthcare. This is expected to increase awareness and better understanding of how work…

Feasibility of transesophageal echocardiography in patients with cardiac arrest in Dutch emergency departments

In the Netherlands, TEE is currently not used in emergency departments during cardiac arrest. The purpose of this study is to investigate if point-of-care TEE can be used effectively and safely in patients with cardiac arrest.

Preparing for heat waves - enhancing human thermophysiological resilience.

Primary objective: To assess the effect of passive heat acclimation, in combination with low-to-moderate intensity exercise, on cardiovascular and thermophysiological responses in overweight, older individuals.Secondary objective: To assess the…

A Randomized, Sham Controlled, Double-blinded, Multi-center Trial to Evaluate the Efficacy of the VentFree Respiratory Muscle Stimulator to Assist Ventilator Weaning in Critically Ill Patients

The primary objective of the trial is to determine whether abdominal FES reduces the duration of invasive mechanical ventilation in critically ill adult patients compared to a sham control.The secondary objectives are to determine whether abdominal…

Movement and Talking of Children with Language and Motor Development Disorders

The aim of this study is to distinguish between persistent language and motor development disorders and temporary delays in language and motor skills in children aged 1 to 6 years, based on indicators in language and motor skills.Main question:Which…

Post-market Clinical Follow-up Study to Provide Safety, Performance and Clinical Benefits Data of the Vanguard PS Open Box Porous Femoral (Implants and Instrumentation) - A Consecutive Series Study

The objective of this retrospective consecutive series PMCF study is to collect long-term data confirming safety, performance and clinical benefits of the Vanguard PS Open Box Porous Femoral (implants and instrumentation) when used for total knee…

Diaphragm paralysis: Surgery or mechanical ventilation?

The following questions will be addressed in the PARASOL study• What is the effect of plication or non-invasive mechanical ventilation on the EQ-5D-5L? o The pilot study is needed as we do not know the clinical relevant effect of both therapies on…

Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients

To assess the safety & feasibility of image-guided mid-treatment hyper-fractioned dose-escalation with proton therapy for the treatment of locally advanced HPV-negative squamous cell oropharyngeal cancer

Assessing blood flow chracteristics across the foramen ovale in term infants during transition at birth: an observational study.

The aims of this study are [1]. to investigate the flow hemodynamics through the foramen ovale (FO) directly after birth and [2]. to assess how these changes are influenced by breathing and the timing of umbilical cord clamping in healthy term…

Effects of sitting interruption frequency on cognitive function and glucose metabolism:
A randomized, controlled cross-over study involving young sedentary adults

The aim is to investigate the effects of breaking up sitting with different frequencies of PA bouts on cognitive function and glucose metabolism in young sedentary adults.

LUNAR-4: Pilot, Single Arm, Open-Label, Multinational Study of Tumor Treating Fields (TTFields, 150 kHz) Concomitant with Pembrolizumab for the Treatment of Metastatic Non-Small Cell Lung Cancer (NSCLC) Previously Treated with a PD-1/PD-L1 Inhibitor and Platinum-Based Chemotherapy

To test the effectiveness and safety of TTFields, delivered using the NovoTTF-200T device, concomitant with pembrolizumab in subjects with metastatic NSCLC previously treated with a PD-1/PD-L1 inhibitor and platinum-based chemotherapy

Glycocalyx restoration in treatment resistant hypertension: a proof of concept, randomized, double-blind, placebo-controlled study

Primary Objective: • To assess whether the food supplement Endocalyx lowers blood pressure in patients with treatment resistant hypertension.Secondary Objectives: • To study the effect of Endocalyx on office blood pressure and 24-hour blood pressure…

Reference values for the Muscle Power Sprint Test (MPST) in children from the age of 5 up to and including 12 years

Our primary goal is to establish generalizable reference values for the MPST in Dutch primary school children aged 5 up to and including 12 years.