Search for a trial

The amount of light to achieve optimal alertness as a function of time of day

This study aims to measure the action spectra of alertness at different time points of the day. The question to be answered is how time-of-day modulates the amount of light that is needed for optimal alertness. This project will result in a dose-…

Neural substrates of anticipatory food reward in healthy males and cancer survivors, investigated with fMRI.

Investigating the neural mechanisms underlying the anticipation of food reward induced by visual cues related to different foodcharacteristics in healthy males would provide 1) brain activity patterns that can be associated with the anticipation of…

A cross-sectional study to assess night-shift work related exposures and their association with markers of biological perturbation

This study aims at, first, assessing the most relevant exposure aspects of night-shift work and, second, identifying biomarkers for both acute and chronic circadian disruption associated to these specific nightshift work aspects. By applying…

Employing dynamic kinetic responses to demonstrate the effectiveness of dietary intervention: A challenge-based study using a low-glycaemic load diet

Primary objective: To assess the impact of a low glycaemic load (GL) diet as compared to a *Western* diet on metabolic flexibility (the change in RQ) upon a hyperinsulinemic euglycemic clamp. Secondary objectives: 1) To assess the impact of low GL…

From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…

The effect of an interdental brush and a water flosser on gingival bleeding and gingival abrasions. A 4 weeks randomized clinical trial.

Primary objective: - What is the effect of the commercially available Water Flosser compared to interdental brushes evaluating gingival bleeding in a group of systemically healthy participants with gingivitis but without periodontitis?Secundary…

Single center ethical protocol for donation of skin tissue and blood samples by patients suffering from psoriasis vulgaris for animal studies concerning development of new treatments for psoriasis vulgaris.

Collection of skin tissue and blood samples from patients with mild to moderate psoriasis for efficacy testing of a reference compound, for subsequent testing of a new therapeutic in a humanized mouse model.

Activation of the innate immune system in patients with primary hyperaldosteronism

The primary objective of the study is to determine whether patients with PA have a higher level of arterial wall inflammation than patients with essential hypertension. Secondary Objectives: To determine whether circulating monocytes of patients…

Cortical mechanisms of vestibular influence on hand choice.

The main objective is to investigate the preparatory process in left primary motor cortex in relation to hand choice during whole-body motion.

A randomized, double-blind, placebo-controlled, parallel, single center study to investigate the pharmacokinetics, safety, and tolerability of Estetrol (E4) in combination with Drospirenone (DSRP) after single and multiple dosing in healthy women.

The purpose of the study is to investigate how quickly and to what extent single and multiple doses of Estelle® are absorbed by and eliminated from the body (this is called pharmacokinetics). It will also be investigated how safe Estelle® is and how…

A Phase I, Open-Label Study to Investigate the Pharmacodynamics and Pharmacokinetics of Etonogestrel (ENG) and 17*-Estradiol (E2) in Healthy Young Adult Women Following Administration of MK-8342B (ENG-E2, 125/300 *g/day) Vaginal Ring for an Extended Period of Time

PrimaryObjective 1: To evaluate the effects of ENG and E2 on ovarian function (pharmacodynamics) when the ENG-E2 vaginal ring (MK-8342B) is used for an extended period of time (i.e., 35 days) in healthy young adult female subjects.Objective 2: To…

A single-center, randomized, open-label, two-arm study to evaluate the ovarian function inhibition of a monophasic combined oral contraceptive (COC) containing 15 mg estetrol (E4) and 3 mg drospirenone (DRSP) and a monophasic COC containing 20 mcg ethinylestradiol (E4)/3 mg drospirenone (Yaz®), administered orally once daily in a 24/4 day regimen for three consecutive cycles

Primary- To evaluate the effects of the 15 mg E4/3 mg DRSP combination and the 20 mcg EE/3 mg DRSP used as reference combination on ovarian function inhibition at Treatment Cycle 1 and Treatment Cycle 3.Secondary- To evaluate levels of luteinizing…

Arterial stiffness, Blood Pressure and Cardiac output study; ABC-study;A Prospective, Multidisciplinary study of arterial stiffness measures in patients treated for aortic aneurysms in relation to blood pressure and cardiac output

Zie document PROTOCOL SYNOPSIS ABC study

The role of the right inferior frontal gyrus braking system in gambling: a transcranial direct current stimulation study

To investigate the effects of anodal and cathodal tDCS on gambling compared to sham stimulation. Additionally, changes in EEG activity will be explored.

ReVENT Sleep Apnea System, a Minimally Invasive Approach to treat Obstructive Sleep Apnea: a Prospective Multicenter Post-Marketing Observational Study

To assess the effectiveness and patient perception of benefit of the ReVENT Sleep Apnea System in patients diagnosed with Obstructive Sleep Apnea due to primary tongue base closure.

Pain education for patients with painful bone metastases undergoing palliative radiotherapy: reducing pain by increasing patient's knowledge and self-management.

The hypothesis of this study is that patient barriers regarding pain management can be diminished by individual nurse-led education (the Pain Education Program), resulting in lower pain intensity and better quality of life of patients.

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SAGE-547 INJECTION IN THE TREATMENT OF SUBJECTS WITH SUPER-REFRACTORY STATUS EPILEPTICUS

Primary objective:To determine the response to a 144-hour (6 day) continuous intravenous infusion of SAGE-547 compared to placebo administered to support the weaning of all third-line agents in subjects with SRSE, and for the response to endure at…

Proteomics analysis of cerebrospinal fluid to investigate brain involvement in pre-eclampsia

The objective of the study is to determine the protein profile of cerebrospinal fluid of non-pregnant women using mass-spectrometry.This study is a follow-up project on the previously performed study (LEPRA, CSF and pre-eclampsia, MEC 2007-087). In…

Fighting fatigue! An intervention to reduce fatigue.

The objective of this study is to develop, test and evaluate a psychosocial intervention for dialysis patients aimed at better coping with, and reducing fatigue (primary outcome) and thus improving the quality of life (secondary outcome).

A randomized, double-blind, placebo-controlled study to investigate the effects of an 8-week recombinant human erythropoietin (NeoRecormon) treatment on well-trained cyclists and their cycling performance.

Primary Objective- To explore the effects of NeoRecormon on well-trained cyclists and their cycling performance by exercise parameters. Secondary Objectives- To explore the effects of NeoRecormon on well-trained cyclists and their cycling…