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Pilot study: A comparison of the extent of haemolysis induced by conventional versus miniaturised extracorporeal circulation during coronary artery bypass grafting surgery, and the influence on the release of damage associated molecular patterns (DAMPs), leukocyte activation and neutrophil extracellular trap (NET) formation.

Primary Objective: To compare the extent of haemolysis associated with the use of the conventional versus the miniaturised heart lung machine in the Amphia hospital, with the aim to set up evidence-based guidelines for the use of a specific type of…

The effect of GBT440 on cerebral perfusion and oxygenation (GBT440-MRI side study)

1. To assess the effect of increased hematocrit on cerebral perfusion as depicted by CBF and CVR.2. To determine the effect of GBT440 on oxygen saturation of the cerebral vasculature and the oxygen local consumption.3. Determine the dose response…

Cerebrovascular Reserve measUrements In Sickle cell diseasE, a MRI-based study

The current study aims to evaluate magnetic resonance imaging (MRI)-based CVR measurements with ACZ in SCD. It*s primary objective is to assess whether there is a correlation between CVR with silent cerebral infarcts (SCI) (i.e. the cerebrovascular…