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Leukocyte dynamics during immune reconstitution after stem-cell transplantation: in vivo labelling of dividing leukocytes using deuterated water

In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.

CT Iterative ReConstruction for Low-dose cardiopulmonary Evaluation: diagnosis of pulmonary infections in patients with febrile neutropenia - Circle Study

To investigate if ultra low-dose chest CT may be a better diagnostic tool than chest X-ray on day 1 of febrile neutropenia. Imaging results will be compared with a consensus diagnosis on the cause of febrile neutropenia made by an expert panel.…

A PILOT PHASE 1, REPEATED SINGLE DOSE STUDY EVALUATING THE VARIABILITY OF PHARMACOKINETICS AND PHARMACODYNAMICS OF LONG ACTING FILGRASTIM FOLLOWING SUBCUTANEOUS ADMINISTRATION TO HEALTHY VOLUNTEERS

To evaluate the inter- and intra-subject variability in pharmacokinetics (PK) and pharmacodynamics (PD) of study drug following a two-period repeated single dose of 2 mg delivered by subcutaneous (SC) injection in healthy volunteers.