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An explorative intervention study to investigate the feasibility and safety of oral immunotherapy with different allergens in young children diagnosed with food allergy.

Primary: Is OIT with standard food products safe to perform in children aged 9 to 24 months with a proven food allergy for hen's egg, peanut, cow's milk, cashewnut, hazelnut, walnut and/or one of the more rare allergens (as soy, pits and…

A 64-week, two-arm, randomized, double-masked, multicenter, phase IIIb study assessing the efficacy and safety of brolucizumab 6 mg compared to aflibercept 2 mg in a treat-to-control regimen in patients with neovascular agerelated macular degeneration (TALON)

To evaluate the efficacy and safety of brolucizumab used in a Treat-to-Control (TtC) regimen for the treatment of patients with neovascular age-related macular degeneration (nAMD) with the objective to evaluate the potential to reduce treatment…

Long term follow-up of the Tendril STS and Isoflex leads in conjunction with the Assurity MRI* and Endurity MRI* Pacemakers within the 3T MRI Environment

The objective of the study is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI* or Endurity MRI* pacemakers, in patients undergoing clinically indicated 3T MRI scans.

Solution Focused Brief Therapy in the multicultural memory clinic: a mixed methods study

In this mixed methods study, the main goals are to determine the effect of solution-focused brief therapy (SFBT) on quality of life (quantitative study) and to describe the influence of SFBT on the experiences, emotions and behaviors of the…

Inference Based Approach (IBA): towards personalized care for OCD patients ;A randomized non-inferiority controlled trial into the effectiveness and working mechanisms of IBA in comparison to CBT.

Primary Objectives: - Is IBA non-inferior to CBT in treating patients with OCD?Secondary Objectives:-* Does treatment modality predict pre- to posttreatment changes in neural networks, and is this related to symptom reduction and changes in…

A randomized, double-blind, two-way cross-over study to determine the effects of levetiracetam on corticospinal excitability in patients with treatment-controlled epilepsy, as measured by single and paired pulse TMS-EMG and TMS-EEG

- To evaluate effects of levetiracetam 2000 mg on single and paired pulse TMS-EMG and TMS-EEG in patients with epilepsy treated with mono-therapy levetiracetam, when compared to placebo (levetiracetam trough concentrations). - To evaluatethe effects…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects with Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed after Prior VEGFR-Targeted Therapy

The objective of this study is to evaluate the effect of cabozantinib compared with placebo on PFS and ORR in subjects with RAI-refractory DTC who have progressed after prior VEGFR-targeted therapy.

A Phase 1, First-in-Human, Double-Blind, Placebo-Controlled, Multicenter, Single and Multiple Ascending Dose Study of NI006 in Patients with Amyloid Transthyretin Cardiomyopathy Followed by an Open-Label Extension

Primary objective:Determine the short- and long-term safety and tolerability of single and multiple doses of NI006 in subjects with ATTR-CM by evaluating adverse events (AE) and serious adverse events (SAE) and changes in laboratory parameters (…

Feasibility, functionality and comfort of a novel concept Ankle-Foot-Orthosis for equinus foot

The objective of this study is to test the feasibility, functionality and comfort of the AFO as an aid to regain the active RoM of the ankle joint in UMND patients with equinus foot. Results of the study will be used to further optimize the AFO…

A Clinical Randomized Controlled RSA Trial Comparing the Cemented ATTUNE (S+Tibia tray) Fixed Bearing Cruciate Retaining Knee System with the Cemented PFC Sigma Fixed Bearing Cruciate Retaining Knee System

The objective of this study is to accurately assess and compare migration, clinical and radiological outcome and patient reported outcomes of two TKR prostheses: the Cemented ATTUNE (S+Tibia component) Fixed Bearing Cruciate Retaining Knee System…

A Randomized, Double-blind, Adaptive, Phase II/III Study of GSK3359609 or Placebo in Combination with Pembrolizumab for First-Line Treatment of PD-L1 Positive Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (study 209229)

Primary: • Compare the efficacy of GSK3359609 in combination with pembrolizumab to pembrolizumab plus placebo in the PD-L1 expression positive (CPS >=1) population and in the PD-L1 expression high (CPS>=20) populationSecondary: •…

A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combinations in myelofibrosis patients

To characterize the safety, tolerability, and recommended phase 2 dose (RP2D) of each combination partner used with ruxolitinib (Part 1)To evaluate the preliminary efficacy of each novel ruxolitinib combination treatment arm (Parts 2 & 3)

Interventional, open-label, exploratory study, investigating the safety, tolerability, pharmacokinetics, and efficacy of Lu AF28996 in patients with Parkinson*s disease

Main objectives:To evaluate the safety and tolerability of Lu AF28996 after up-titration of oral dose(s) in patients with Parkinson's Disease (PD)To investigate the pharmacokinetic properties of Lu AF28996 after up-titration of oral dose(s) in…

Sleep positional therapy for the treatment of nocturnal gastroesophageal reflux

The main objective of the study is to assess the effect of sleep positional therapy, using the LEFT device, on nocturnal gastroesophageal reflux.

HELIOS-A: A Phase 3 Global, Randomized, Open-label Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients with Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

This study has been transitioned to CTIS with ID 2023-508365-33-00 check the CTIS register for the current data. To determine the efficacy of ALNTTRSC02 in patients with hATTR amyloidosis by evaluating the effect on neurologic impairment. To…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the
Efficacy and Safety of AG10 in Subjects with Symptomatic Transthyretin
Amyloid Cardiomyopathy (ATTRibute-CM Trial)

Key PrimaryPart A• To determine the efficacy of acoramidis (AG10) in the treatment of subjects with symptomatic transthyretin amyloid cardiomyopathy (ATTR-CM) by evaluating the difference between the acoramidis and placebo groups in the change from…

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Crohn's Disease

MAIN Trial:Primary:To evaluate whether the efficacy of mirikizumab is superior to placebo in participants with Crohn's disease as assessed by- clinical response by patient reported outcome (PRO) at Week 12 andendoscopic response at Week 52-…

A Phase 2, Multicohort Open-Label Study of JNJ-68284528, a Chimeric Antigen Receptor T cell (CAR-T) Therapy Directed Against BCMA in Subjects with Multiple Myeloma

This study has been transitioned to CTIS with ID 2023-506587-13-00 check the CTIS register for the current data. The safety and efficacy of JNJ-68284528 in heavily pretreated patients with multiple myeloma is being evaluated in the Phase 1b/2 Study…

Deep brain stimulation for refractory tinnitus

The goal is to assess the effect of MGB-DBS on tinnitus severity. Secondary objectives are:- To assess side effects of MGB-DBS on hearing and neuropsychological functioning.- To explore neurophysiological hallmarks.

Pragmatic randomised controlled study to assess the effectiveness of two patient management
strategies in mild-to-moderate Ulcerative Colitis

The purpose of this pragmatic randomised controlled study is to compare two patient management strategies in mild-to-moderate UC disease. The goal of the study is to propose a new patient management strategy to both physicians and patients, as an…