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The supplementary role of cardiovascular magnetic resonance imaging and computed tomography angiography to routine clinical practice in suspected non-ST elevation myocardial infarction.
A randomized controlled trial.

Primairy objectives:1.To investigate whether a non-invasive imaging guided strategy (either CTA or CMR) early in the diagnostic process reduces the number of patients with at least one ICA during the initial admission as compared to routine clinical…

Physical trauma patients with symptoms of an acute stress disorder: an observational study

Primary objective: to examine the natural course of ASD symptoms Second objective: to determine the effects of ASD symptoms on the development of PTSD and patients* psychological distress (i.e., anxiety and depressive symptoms), coping, and QOL…

Laparoscopic advanced Imaging Techniques in Endometriosis therapy: the LITE study. A pilot trial.

To determine which advanced image enhanced modality is the most feasible for the detection of endometriosis lesions, with respect to the specificity and sensitivity of the investigated modalities. To determine which imaging modality reveals more…

99mTc-mebrofenin Hepatobiliary Scintigraphy (99mTc-HBS) liver function stress test - liver reserve capacity and age dependant changes in liver function - CHOCOLATE STRESS TEST

In this study we will explore changes in the hepatic function after stimulation of hepatic cells with an oral food challenge, the **hepatocyte reserve capacity**. Moreover, we will explore potential differences in the hepatocyte reserve capacity…

Investigation of the signature of recurrence and radiation effects after External-Beam Radiotherapy of prostate cancer on multi-parametric MRI

Primary objective: • Investigate the signature of recurrent prostate cancer and of radiation effects after external-beam radiotherapy on multi-parametric MRISecondary objective: • Identify imaging features that are characteristic of recurrent…

Measuring work-of-breathing in mechanically ventilated children

The primary objective for this study is to compare the level and time course of the patient work-of-breathing during PS ventilation with the work-of-breathing during SIMV-PS ventilation with a lower rate of breaths per minute delivered by the…

The sensitivity of scar-biopsies for residual colorectal adenocarcinoma after endoscopic resection with uncertain radicality.

To evaluate the sensitivity of second-look endoscopic biopsies from the polypectomy site for residual adenocarcinoma in the surgical resection specimen.To register patients in whom exclusion criteria exist, in order to prospectively evaluate the…

The use of indocyanine green for accurate sentinel node detection and removal in a group of high-risk nodal metastasis prostate cancer patients
To optimize and improve the sentinel node procedure in men with prostate cancer

The overall goal of this study is to further validate and improve the sentinel node procedure for prostate cancer using ICG-99mTc-nanocolloid. The first objective aims at further validation of the sentinel node procedure for prostate cancer via…

Biological variation of cardiac biomarkers in aortic valve stenosis

To study the biological variation of cardiac biomarkers (e.g. cardiac troponin T and I, NT-pro-BNP, ST-2, Galectin-3) in clinically stable moderate aortic valve stenosis.

Grumpy or depressed? Disentangling normative irritability from early signs of depression among adolescents with cell-phone micro-measures of daily mood swings.

Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…

Resting state functional MRI in term neonates with perinatal asphyxia

To determine the feasibility of rs-fMRI in neonates undergoing a planned diagnostic MRI session following perinatal asphyxia. To assess intra-session reproducibility (test-retest reliability) of the rs-fMRI technique in neonates with asphyxia.

The addition of STEPPS in the treatment of patients with bipolar disorder and comorbid borderline personality features: an open pilot study

Little research is being done on the effects of psychological treatment in patients with a bipolar disorder (BD) and comorbide borderline personality disorder (BPD) features. There are no recommendations included in the guideline for BD (Nolen et al…

Posttraumatic osteoarthritis following perilunate dislocations and perilunate fracture dislocations in young patients and the correlation with subjective and objective outcome measures. A descriptive cohort study.

To determine the prevalence of posttraumatic osteoarthritis following a PLD-PLFDs in a cohort of young non-osteoporotic patients and correlation with objective and subjective outcome measures.

Robot-aided system identification (ROBIN) of neural and non-neural contributors to ankle joint impedance in children with CP

Primary objective of this study is to assess the reliability and validity of the neuromuscular parameters of ankle joint impedance estimated by nonlinear SIPE technology in children with CP compared to current clinical manual tests and gait analysis…

Microvolt T-Wave Alternans in Adults with Congenital Heart Disease: a Predictor of Ventricular Arrhythmias

Primary Objective: to determine the prevalence of MTWA in adults with congenital heart disease who are deemed to be at high risk for ventricular arrhythmias and sudden cardiac death.Secondary Objective(s): • to describe the clinical usefulness and…

Quantitative Sensory Testing in Failed Back Surgery Syndrome and Complex Regional Pain Syndrome Patients during Dorsal Root Ganglion stimulation

The primary objective of this study is to investigate attenuation of pain and sensory thresholds during dorsal root ganglion stimulation using QST. The secondary objectives of this study are to investigate 1) To assess changes in pain intensity (NRS…

Exploring the use of optical coherence tomography and hyperspectral imaging in glioma detection during surgery

Primary Objective: To assess whether both OCT (optical coherence tomography) and/or HSI (hyperspectral imaging) detect differences in glioma tissue as compared to healthy tissue as examined during brain-surgery.Secondary Objective(s): To assess if…

Bariatric procedures and changes in gut hormones and gastric passage

To assess and compare the gastric emptying rate and gut hormone levels between patients one year after standard RYGB (S-RYGB), B-RYGB and EP-RYGB.

Non-invasive assessment of lung remodeling in patients with idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) using [11C]-Nintedanib or [18F]-FLT PET imaging.

To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.

Optimizing lung imaging in people with Ataxia Telangiectasia applying improved MRI techniques.

The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…