The aim of the study is to evaluate the effect of stroke volume variation on different parameters of peripheral perfusion. Additionally the relationship between these parameters will be studied.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
fysiologie van de relatie van micro- en macrocirculatie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is the peripheral perfusion assessed by 1) laser
doppler flowmetry, 2) sidestream dark field imaging, 3) near infrared
spectroscopy, 4) photopletysmography.
Secondary outcome
Not applicable.
Background summary
Intravenous administration of fluids is one of the cornerstones of treatment of
hemodynamically instable patients admitted to the intensive care. The aim of
fluid administration is improving tissue perfusion. The effect however is
mainly assessed by the increase of cardiac output and stroke volume. Currently
there is no clinical parameter which objectively evaluates the effect of fluid
administration on tissue perfusion. New techniques are available which are able
to assess tissue perfusion non-invasively. Healthy volunteers will be studied
because they are by definition fluid responsive and the peripheral perfusion
will be adequate. By studying this population the physiological relationship
between stroke volume and peripheral perfusion can be determined. It is
possible that one or more of these parameters are capable to guide the fluid
regime on the individual needs of the patient based on the tissue perfusion.
Study objective
The aim of the study is to evaluate the effect of stroke volume variation on
different parameters of peripheral perfusion. Additionally the relationship
between these parameters will be studied.
Study design
The study will be carried out in the Erasmus Medical Center and will be carried
out as a single center observational study.
Study burden and risks
The posture changes are temporary and do not involve any risks. The methods to
measure peripheral perfusion are based on light with harmless wavelengths. The
measurement probes will only slightly make contact with the skin and the
sublingual area of the subject. The duration of the study for the individual
subject is 1 hour.
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Age above 18 years
Exclusion criteria
Cardiovascular diseases
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27840.078.09 |