The objectives of this pilot are (1) to test and develop an experimental setup to determine contrast sensitivity, visual field and adaptation time at high light conditions. (2) To perform a pilot study with 10 healthy subject.
ID
Source
Brief title
Condition
- Glaucoma and ocular hypertension
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Measurement of contrast sensitivity, visual field and adaptation time at high
light conditions.
Secondary outcome
N/A
Background summary
Many patients with glaucoma experience difficulties while seeing in light and
dark conditions. These difficulties are not only present in patients with
severe glaucoma, but also in patients with a normal visus and an intact visual
field. We already researched the influence of light- and dark conditions using
a questionnaire (METc 2014/338) and confirmed the difficulties described above.
In addition, patients with glaucoma experience longer light- and dark
adaptation times compared with healthy subjects. In a former project (METc
2014/409) we researched the influence of static low light conditions and in the
project that followed (METc 2015/276) we researched the adaptation time to low
light conditions. In the pilot of this application, we continue with the
influence of high light intensities on the contrast sensitivity, visual field
and adapation time. There is no literature available of the influence of high
light intensities. There is no device available yet to provide these
intensities.
Study objective
The objectives of this pilot are
(1) to test and develop an experimental setup to determine contrast
sensitivity, visual field and adaptation time at high light conditions.
(2) To perform a pilot study with 10 healthy subject.
Study design
Pilot study
Study burden and risks
A single visit, in which the contrast sensitivity, visual field and adaptation
time at high light conditions will be measured. There are few extra tests to
check the healthy state of the eye. Total time invested 2 hours. It is possible
that an eye disease is discovered during the course of this study. The
resulting psychological stress to the subject can be a disadvantage. However,
the advantage is an early start of adequate treatment. All measurements are
conducted using optical techniques that do not touch the eye and therefore are
completely harmless. There is no risk during the experiments. No mydriasis
(pupil dilation) will be implemented.
Hanzeplein 1
Groningen 9700 RB
NL
Hanzeplein 1
Groningen 9700 RB
NL
Listed location countries
Age
Inclusion criteria
Healthy subjects will consist of people (age 18-70) who have signed in, without ophthalmic abnormalities and provide written informed consent.
Exclusion criteria
- Subjects with an eye disease.
- Subjects with a first degree relative with glaucoma, or with high eye pressure in the past.
- Visual acuity below 1.0 (below 50 years of age) or below 0.8 (above 50 years of age).
- Visual field defects which are not understood.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| Other | 201501071(UMCG Research Register) |
| CCMO | NL55530.042.15 |