To determine whether analysis of extra systoles can predict fluid responsiveness
ID
Source
Brief title
Condition
- Coronary artery disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate if post-ectopic induced changes in blood pressure before a fluid
bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume
Secondary outcome
To investigate a mini fluid challenge*s effect on blood pressure and to
investigate if mini fluid challenge induced changes in hemodynamic variables
and in trans-oesophageal echocardiographic variables can predict how fluid
bolus induce changes in cardiac function.
Background summary
In this study, we propose to investigate a novel technique for fluid
responsiveness prediction. It is based on the occurrence of an extra systole,
which induces a preload variation: Extra systoles are comprised by, first, the
premature/ectopic beat with decreased cardiac preload, then, the post-ectopic
beat with moderately increased preload. Consequently, the post ectopic beat is
associated with a Frank-Starling curve right shift but is otherwise a normal
sinus beat. As such, the post-ectopic beat elucidates and predicts the
hemodynamic effect of increasing preload, i.e. giving fluids
Study objective
To determine whether analysis of extra systoles can predict fluid
responsiveness
Study design
Interventional prospective study
Study burden and risks
The structured observations prior to and during a fluid bolus is the only
intervention in this study.
hanzeplein 1
groningen 9713 EZ
NL
hanzeplein 1
groningen 9713 EZ
NL
Listed location countries
Age
Inclusion criteria
- Patients requiring elective CABG or OPCAB surgery
- Patient*s age >= 18 years
Exclusion criteria
- Patient refusal
- Pregnancy
- EF < 35%
- End stage kidney failure (defined by the need for haemodialysis)
- Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58966.042.16 |