The objective of the study is to evaluate the cerebellar symptoms in children with OMS diagnosed and treated at the Sophia Children*s Hospital.
ID
Source
Brief title
Condition
- Central nervous system infections and inflammations
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The study will have multiple endpoints:
* Computer-assisted assessments:
- Eye tracking: smooth pursuit and saccades;
- Balance plate: scatter in center-of-gravity;
Secondary outcome
* Clinical endpoints
- OMS rating scale score;
- SARA-score.
* Computer-assisted assessments:
- Score *Shelby*s Quest*.
* Questionnaires;
Background summary
Most OMS patients have residual symptoms, despite aggressive treatment. Due to
the probable involvement of the cerebellum, elaborate cerebellar testing may
give a precise assessment of the disease activity. These assessments may be a
valuable tool in the clinic, as they may be used as a guideline to intensify or
alter current treatment.
Study objective
The objective of the study is to evaluate the cerebellar symptoms in children
with OMS diagnosed and treated at the Sophia Children*s Hospital.
Study design
A cross-sectional study
Study burden and risks
not applicable
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
All patients with OMS, diagnosed and treated at the Sophia Children*s Hospital will be included. OMS is defined as the presence of *3 of the following symptoms: [1] opsoclonus, [2] myoclonus and/or ataxia, [3] behavioural change and/or sleep disturbance and [4] neuroblastoma.
Age-matched children with pilocytic astrocytoma, diagnosed and treated at the Sophia Children*s Hospital will be included.
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Insufficient command of the Dutch language (spoken and/or written)
- Age above 12 years
Children with pilocytic astrocytoma will be excluded from participation, when they were treated with radiotherapy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL60317.078.17 |