The primary objective is to compare the amount and types of AGEs of the arterial wall of both PAOD and AAA in patients with and without DM.
ID
Bron
Verkorte titel
Aandoening
Patients with an abdominal aortic aneurysm (AAA) or peripheral arterial occlusive disease (PAOD) with and without diabetes mellitus.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Advanced glycation end products in the arterial wall
Achtergrond van het onderzoek
Peripheral arterial occlusive disease (PAOD) and abdominal aortic aneurysms (AAA) are thought to have different pathophysiology. PAOD and AAA share smoking as major risk factor. However, DM is a common risk factor for occlusive vascular disease, but a protective factor for dilating disease. Accumulation of advanced glycation end products (AGEs) in the arterial wall could possibly explain the different effects of DM on these diseases. AGEs are sugar-modified moieties forming on proteins which are formed under influence of oxidative and glycemic stress. AGEs have the potential to create cross-links and to induce inflammatory and oxidative stress responses after binding to the receptor for AGE. Increased accumulation of AGEs is associated with increased risk of cardiovascular morbidity and mortality in several diseases, including PAOD.
Doel van het onderzoek
The primary objective is to compare the amount and types of AGEs of the arterial wall of both PAOD and AAA in patients with and without DM.
Onderzoeksopzet
Visit before surgery: vascular lab + laboratory for blood and urine.
Return 24h urine.
Surgery
Onderzoeksproduct en/of interventie
None
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age > 18 years old.
AAA or PAOD
Scheduled for open surgical repair of an AAA or bypass surgery or endarterectomy for PAOD.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Both AAA and PAOD
Inflammatory disease (rheumatoid artritis, SLE, giant cell artritis, Takayasu disease)
Inflammatory/mycotic aneurysm
Connective tissue disease (Marfans disease/ Ehlers-Danlos disease)
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5215 |
| NTR-old | NTR5363 |
| CCMO | NL45660.042.14 |
| OMON | NL-OMON45188 |