Eltrombopag increases platelet activity and alters immune profiles in ITP
ID
Bron
Verkorte titel
Aandoening
Immune thrombocytopenia (ITP)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Change in immunologic profile and platelet function before start and during treatment with eltrombopag
Achtergrond van het onderzoek
It has been suggested that prolonged use of TPO-receptor agonists (TPO-RA) can result in immune tolerance induction in patients with immune thrombocytopenia (ITP). However, little is known about the effect of this kind of immune modulation on B- and T-cell profiles in ITP. Furthermore, the use of TPO-RA is associated with an increased rate of thromboembolic events, suggesting the possibility that TPO-RA alters the platelet function. The aim of this study is to test our hypothesis that TPO-RA increases platelet activity and alters immune profiles in ITP.
Doel van het onderzoek
Eltrombopag increases platelet activity and alters immune profiles in ITP
Onderzoeksopzet
Before start of eltrombopag, and at 2-3 weeks, 3, 6 and 12 months
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age 16 years and older
- Previously confirmed diagnosis of primary ITP with current platelet counts of <100x109/L
- Will start treatment with eltrombopag
- Willing and be able to understand the study information and sign the informed consent form.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Documented history of persisting severe anemia (defined as hemoglobin <6.0 mmol/L for men and women)
- Treatment with rituximab in the past 9 months
- Treatment with any immune modulating drug other than corticosteroids in the past 3 months
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8614 |
| Ander register | METC UMCU : METC 18-859 |