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Empowerment of personal injury victims.

The internet intervention will enhance empowerment, perceived justice, wellbeing and knowledge of personal injury victims during claims settlement.

The effect of protein hydrolysate supplementation to preserve muscle mass during immobilisation and enhance muscle regain during recovery

We hypothesize that protein hydrolysate supplementation will attenuate the loss in muscle mass during 7 days of immobilisation and will augment the rate of muscle mass re-gain during recovery.

Treatment of Fabry patients > 18 years with enzyme supplementation therapy: comparison of efficacy and toxicity of low dose (0,2 mg/kg) fabrazyme (agalsidase beta) or replagal (agalsidase alfa).

Evaluation of efficacy and safety of two different formulas of alfa-Galactosidase A, agalsidase beta (FabrazymeTM) and agalsidase alpha (ReplagalTM) in an equal dose of 0,2 mg/kg in order to detect any differences between these two drugs.

Analyzes of pathogen and host determinants in hospitalized patients with a laboratory confirmed infection caused by Staphylococcus aureus: the PATHOS Study.

To identify candidate antigens for the development of a prophylactic Staphylococcus aureus vaccine by studying expression profiles of host and pathogen determinants during natural infection.

Leiden-Alloimmunization-Likelihood (LAL)trial.

The use of by filtration-leukocyte reduced blood transfusions in patients undergoing cardiac surgery, will result in lower alloimmunization frequencies compared to using buffy-coat depleted blood transfusions. This has previously been shown in…

Botulinum toxin in the treatment of orofacial tardive dyskinesias: a single blind study.

Botulinum toxin A declines the severity of tardive dyskinisias.

The effect of computer reminders on prescribing behaviour of GPs.

We hypothesised that this strategy could lead to a considerable and relevant change of prescribing behaviour in the desired direction.

Onderzoek naar de relatie tussen huidvetten en wrijving tussen huid en textiel

Myelo-ablative chemo/radiotherapy and autologous stem cell transplantation as compared to only chemotherapy in patients with multiple myeloma.

The hypothesis to be tested is that the outcome in arm II (and Allo BMT) is better than in arm I.

TIP-glucocorticoids research UMCU rheumatology; Cardiovascular risk factors and insulin resistency in reumatoid arthritis patients with and without glucocorticoids.

What is the relation between disease activity, treatment, and metabolic syndrome / insulin resistance.

THE GLOBAL RANDOMIZED NBI BLADDER CANCER STUDY -A Multi- Centre, International study to compare use of Narrow Band Imaging (NBI) versus White light (WL) during TURB to assess recurrence of bladder cancer in terms of safety and efficacy.

To compare the recurrence rate at 1 year following Narrow Band Imaging and TURB (Arm A) with White Light Trans Urethral Resection of Bladder cancer (TURB) (Arm B) in patients with non muscle invasive (NMIBC Ta/T1) bladder cancer.

Is the use of bloodplatelets effective in the treatment of difficult fistulas related to the anal sfincter?

The use of platelets in addition to mucosa advancement flap in the treatment of complex peri-anal fistula will reduce the recurrence rate of these fistulas.

A double-blind, randomised, placebo-controlled trial of prolonged antibiotic treatment after intravenous ceftriaxone in patients with (possible) persistent Lyme disease.

Prolonged antibiotic treatment of patients diagnosed with presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.

Consumenten Studie Mexico

The different processing of formulas will have an effect on stool characteristics such as consistency, frequency, amount and colour.

Effect of synbiotics in infants with atopic dermatitis up to 7 years of life.

A positive effect of the study product in preventing asthma like symptoms in infants at high risk for developing asthma later in childhood.

Early treatment of central serous retinopathy by photodynamic therapy. A randomized controlled trial.

Visual outcome in CSR patients is superior when treated by Photodynamic Therapy (PDT) compared to observation.

Timing of providing ankle-foot orthoses in stroke rehabilitation.

Early provision of AFOs (± 2 wks after stroke) is expected to positively affect walking impairments, mobility and activities of daily living after acute stroke compared to providing AFOs later on in the rehabilitation process (± 10 wks after stroke…

High-Flow Nasal Cannula for severe COVID-19, a multicentre prospective cohort study

1) In what proportion of severe hypoxic COVID-19 patients on HFNC is invasive mechanical ventilation necessary? 2) In what proportion of severe hypoxic COVID-19 patients with an DNI code on HFNC results in progressive respiratory failure or death?

A randomised, double-blind, placebo-controlled study to evaluate the efficacy of imiquimod 5% in women with Vulvar Intraepithelial Neoplasia (VIN) 2 and 3.

Imiquimod, an immunomodulator, has been shown safe and effective in the treatment of external genital warts caused by low risk human papillomavirus (HPV). Therefore, it is hypothesized that this topical treatment may also be effective against…

The No Moni study

The sugammadex dose required to achieve a TOF-ratio of 1 is not known when monitoring is not used. Administration of sugammadex based on the rocuronium dosage, while aiming for complete recovery, should reduce the risk of residual NMB.