No registrations found.
ID
Source
Health condition
Type 2 diabetes, first-degree relatives of type 2 diabetic patients, insulin resistance, mitochondrial function
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Ex vivo mitochondrial function;
2. In vivo mitochondrial function;
3. Insulin sensitivity;
4. Fat accumulation in muscle and heart;
5. Indirect calorimetry.
Secondary outcome
1. Plasma glucose;
2. Plasma insulin;
3. Plasma free fatty acids;
Background summary
We found a reduced basal ADP-stimulated and maximal mitohondrial respiratory capacity related to type 2 diabetes, which underlies the reduction in in vivo mitochondrial function, independent of mitochondrial content.
Study objective
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
Study design
1. All metabolic measurements for one patient planned within one month.
2. All subjects underwent these metabolic measurements within 1.5 year.
Intervention
No intervention is performed.
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Inclusion criteria
1. Well controlled type 2 diabetic patients;
2. Normoglycemic first-degree relatives with at least one first-line family member diagnosed with type 2 diabetes;
3. Normoglycemic control subjects;
4. BMI 27 - 30 kg/m2;
5. Age 50- 70 y.
Exclusion criteria
1. Uncontrolled hypertension;
2. Active cardiovascular disease;
3. Liver disfunction;
4. Medication known to interfere with glucose metabolism (except for diabetic patients).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL1956 |
NTR-old | NTR2074 |
Other | METC Maastricht University Medical Center : 04-257 |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |
Summary results
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Diabetes, VOL 57, November 2008.