Research with human participants

Overview of medical research in the Netherlands

Lipid-induced mitochondrial dysfunction in type 2 diabetes.

No registrations found.

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Ethical review
Positive opinion
Status
Suspended
Health condition type
-
Study type
Observational non invasive

ID

NL-OMON20007

Source

Nationaal Trial Register

Health condition

Type 2 diabetes, first-degree relatives of type 2 diabetic patients, insulin resistance, mitochondrial function

Sponsors and support

Primary sponsor :
Maastricht University Medical Centre, Maastricht, The Netherlands.
Source(s) of monetary or material Support :
Diabetes foundation (DFN), The Netherlands

Intervention

Outcome measures

Primary outcome

1. Ex vivo mitochondrial function;

2. In vivo mitochondrial function;

3. Insulin sensitivity;

4. Fat accumulation in muscle and heart;

5. Indirect calorimetry.

Secondary outcome

1. Plasma glucose;

2. Plasma insulin;

3. Plasma free fatty acids;

Background summary

We found a reduced basal ADP-stimulated and maximal mitohondrial respiratory capacity related to type 2 diabetes, which underlies the reduction in in vivo mitochondrial function, independent of mitochondrial content.

Study objective

Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?

Study design

1. All metabolic measurements for one patient planned within one month.
2. All subjects underwent these metabolic measurements within 1.5 year.

Intervention

No intervention is performed.

Public
Postbus 616
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl
Scientific
Postbus 616
Department of Human Biology
Maastricht University Medical Center
Patrick Schrauwen
Department of Human Biology
Maastricht University Medical Center
Maastricht 6200 MD
The Netherlands
+31(0)43-388 15 02
p.schrauwen@hb.unimaas.nl

Inclusion criteria

1. Well controlled type 2 diabetic patients;

2. Normoglycemic first-degree relatives with at least one first-line family member diagnosed with type 2 diabetes;

3. Normoglycemic control subjects;

4. BMI 27 - 30 kg/m2;

5. Age 50- 70 y.

Exclusion criteria

1. Uncontrolled hypertension;

2. Active cardiovascular disease;

3. Liver disfunction;

4. Medication known to interfere with glucose metabolism (except for diabetic patients).

Design

Study type :
Observational non invasive
Intervention model
:
Parallel
Allocation :
Non controlled trial
Masking :
Open (masking not used)
Control :
N/A , unknown

Recruitment

NL
Recruitment status
:
Suspended
Start date (anticipated) :
Enrollment :
60
Type :
Anticipated

Positive opinion
Date :
Application type :
First submission

Followed up by the following (possibly more current) registration

No registrations found.

Other (possibly less up-to-date) registrations in this register

No registrations found.

In other registers

Register ID
NTR-new NL1956
NTR-old NTR2074
Other METC Maastricht University Medical Center : 04-257
ISRCTN ISRCTN wordt niet meer aangevraagd.

Summary results

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.
<br>
Diabetes, VOL 57, November 2008.