35348 results
The primary objective of this study is to assess the relation between the short term metabolic changes after start of rhGH therapy and the long term change in height SDS after one year of treatment. Secondly, we want to assess the effects of GH on…
The aim of this study is to create a prognostic model enabling the clinician to predict the outcome of a septic episode. Furthermore, by getting more insight in the pathophysiologic proces of sepsis, we could discover new possible targets for future…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
Identifying translational EEG endophenotypes in mice and man that will determine cross-species genetic findings on behavioural and cognitive traits, including psychiatric disorders.
To investigate whether bowel relaxation, induced by administration of hyoscine N-butylbromide, improves the detection, removal and colllection of lcolonic polyps during colonoscopy
Primary Objective: Our primary objective is to investigate the effect of NAC on H2S levels in plasma in different patient groups, i.e. healthy volunteers, CKD patients, and dialysis patients. We hypothesize that there is an increase in H2S levels…
To determine the effect of hypoglycaemia on BAT-activity.
We will investigate endothelial function before and after bariatric surgery.
Certolizumab pegol is a PEGylated humanized Fab* fragment with specificity for humanTNF*. Certolizumab pegol has demonstrated efficacy in clinical studies of Crohn*s disease(CD), psoriasis (PSO), and RA. The objective of this study is to demonstrate…
The aim of the study is three-fold: First to reveal the clinical course of overweight, second to reveal the clinical course of complaints in overweight and non-overweight children and third to identify leads for prevention of (sustained) overweight…
In our study we aim to find proof-of-concept that influencing the underlying protein dysfunction can result in clinically relevant improvement of epilepsy.
In a randomized clinical setting are two treatment methods for primary molars with caries were compared:- indirect pulpcapping sealed with a stainless steel crown - excavate al caries and sealed with a stainless steel crown, and if necessary, a…
The aim of this project is to elucidate how corticosteroids protect cardiac surgical patients from PNAF. We will therefore examine the modulating effect of prophylactic high-dose corticosteroid administration on perioperative risk factors for PNAF.…
We aim to observe in whole blood at patients core temperature and normotemperature how mild therapeutic hypothermia affects coagulation and in particular fibrinogen, in post cardiac arrest patients.
Part A Food Effect StudyPrimary Objective• To determine the effect of a high fat meal on oral bioavailability of 50 mg E7820 in comparison with fasting conditions.Secondary Objectives• To determine the safety and tolerability of E7820.• To determine…
(1) To assess the effect of ARA 290 on the ventilatory response to hypoxia (and compare the effects to Epo); (2) To assess the effect of ARA 290 on the gradient over the tricuspid valve during hypoxia (and compare the effects to Epo); (3) To assess…
treatment of overweight persons with insulinresistance with a low dose metformine add to yoghurt The early reduce of glucose especially the postprandial will hopefully decrease this process. This reduce of the glucose only needs to be 1 mmol and we…
To determine the test-retest reliability and agreement of the neck-FCE in patients with chronic non-specific neck pain.
This study will contribute to improving quality of care for cancer survivors, since sexual problems seem to be profound but not always discussed with patients. Patients are now often insufficiently informed and do not know how to interpret their…
To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness and decidual acceptance (the quality of decidualization, endometrium-embryo communication and endometrial stromal cell (ESC) migration) and B) the angiogeneic…