1242 results
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
To evaluate the validity of grip work and self-perceived fatigue measured with the eforto® system for monitoring hip fracture recovery and insight in resilience.
The primary study endpoint is the respiratory exchange ratio (RER) during the night. The secondary objectives are to examine how differentially timed exercise affects 1) 24h energy and substrate metabolism and 2) the immune response based on…
The primary objective of this study is to determine brain activation in response to olfactory (orthonasal) exposure to different fat levels contained in a ecologically-relevant fat source.
1. study the effects of an 8-week high-intensity interval training on motor and non-motor aspects (primary outcome: anxiety and depression) of Parkinson's disease and Multiple Sclerosis, compared to traditional continuous aerobic training and…
- to explore the decline in renal concentration ability (RCA) in a Dutch population of lithium treated patient - to explore the decline in kidney function
1. To report the natural history of retinal degenaration in patients with biallelic mutations in the PCDH15 gene.2. To identify sensitive structural and functional outcome measures to use for future multicenter clinical trials in PCDH15-related…
Primary Objective:Delineate the differences in cellular composition and function at the maternal-fetal interface in patients with SLE compared to healthy women Secondary Objectives:- Establish a novel in-vitro model to study cell-cell interaction at…
Objective: The primary objective of this study is to investigate interoceptive abilities in adolescents with AN. To capture the multidimensional perspective, interoceptive abilities will be studied on an accuracy, sensibility and awareness level.…
The primary objective of this secondary prevention study is to evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics of gantenerumab, an anti-amyloid antibody, in amyloid-positive, cognitively unimpaired participants at risk for or…
The study*s main objective is to measure blood micro- and macronutrient and amino acid levels in adults with PKU on a protein substitute and compare with age- and sex-matched non-PKU comparison subjects.
To compare the post-prandial muscle protein synthetic response following ingestion of a whole-food meal (560kCal; 30g protein total) before and after a 8-week passive heat treatment intervention in healthy older men and women.
Although this procedure has been performed for more than 20 years and clinical results after myectomy combined with AMVLE are satisfactory, very little is known about the effect of surgical myectomy intervention on the blood flow through the aortic…
This study has been transitioned to CTIS with ID 2024-518865-85-00 check the CTIS register for the current data. Primary objectiveEvaluation of [18F]MC225 to measure the P-glycoprotein function in Alzheimer*s disease, Mild Cognitive Impairment and…
The purpose of this study is to evaluate the safety and effectiveness of the Aveir wireless dual-chamber pacemaker system in the treatment of patients with slow or irregular heartbeats.
The primary objective is to investigate the effect of 6 weeks porcine protein supplementation versus an isocaloric carbohydrate (maltodextrin) on the composite endpoint of physical recovery.
To investigate the impact of the daily consumption of a mealworm- and whey protein supplement on muscle damage upon physical exercise in vital active elderly.
To identify host risk factors through genetic and immunological screening that may be associated with the development of cardiac SAEs following CHMI. Identification of such factors may on the one hand allow at-risk individuals to be screened out…
Primary Objective:To investigate the effect of respiratory and physical exercises in VR on pulmonary recovery compared to the standard of care of patients suffering from blunt chest trauma.Secondary Objective(s):- To investigate if VRx can improve…
Primary Objective: 1. To investigate the effect of CRT on markers of pancreatic exocrine functioningSecondary Objectives: 1. To compare changes in markers of pancreatic exocrine function between CRT responders and non-responders2. To compare the…