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A Randomized, Double blind, Placebo controlled Clinical Study to Evaluate
Mavacamten (MYK-461) in Adults with Symptomatic Obstructive
Hypertrophic Cardiomyopathy

Primary Objective* To compare the effect of a 30-week course of mavacamten with placebo on clinical response comprising of exercise capacity and clinical symptoms in participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM)…

A Long-term Safety Extension Study of Mavacamten (MYK-461) in Adults
with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICKHCM
(MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE)

This study has been transitioned to CTIS with ID 2022-502858-14-00 check the CTIS register for the current data. primary objective:To assess the long-term safety and tolerability of mavacamten in participants with hypertrophic cardiomyopathy (HCM)…

A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

This study has been transitioned to CTIS with ID 2023-506352-24-00 check the CTIS register for the current data. Primary Objectives: • To assess the efficacy of a 48-week course of mavacamten compared to placebo on patient- reported health status (…