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Selective D1 activation by addition of L-Dopa to antipsychotic treatment in patients with schizophrenia

To examine the effect of L-dopa addition to optimal D2-blocking antipsychotic treatment on positive symptoms, negative symptoms, cognitive symptoms and extrapyramidal symptoms in schizophrenia.

Dopaminergic modulation of cognition and psychomotor function

To replicate and extend the findings of the recent methylphenidate study in which methylphenidate was found to enhance episodic memory performance; To explore whether this effect of methylphenidate is primarily mediated by its dopaminergic action.

A single dose Levodopa study to balance goal-directed and habitual behavior in schizophrenia

to assess whether a single-dose of levodopa improves cognitive symptoms and balances goal-directed and habitual behavior.

A double blind, randomized, placebo controlled four way cross-over trial to investigate the effects of metoclopramide on central vasopressin release and HPA-axis activation

Primary:1. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol secretion in the absence of a 5HTP-challenge.2. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol…

Motor function optimization in advanced Parkinson*s disease patients, combined with galantamine to prevent visual hallucinations.

To investigate the effects of galantamine on cognitive impairment and visual hallucinations in Parkinson`s disease, both therapeutic (direct effect) and preventive (protection against an acute increase of dopaminergic medication used by the patient…

A double-blind, randomized, placebo controlled, single oral dose, two way cross-over trial to investigate the effects of an orally administered 5-HTP challenge test on hypothalamic fMRS activation in healthy male volunteers.

Primary Objectives:- To investigate the effects of a single dose (plasma concentration) 5-HTP challenge test (5-HTP200mg/CBD100+50mg/granisetron2mg) on hypothalamic fMRS activation patterns in healthy male volunteers.Secondary Objectives:- To assess…

A NON-RANDOMIZED, OPEN-LABEL, CROSS-OVER, DRUG-DRUG INTERACTION STUDY TO EVALUATE THE EFFECTS OF BIA 28-6156 AT STEADY-STATE ON THE PHARMACOKINETICS OF LEVODOPA/CARBIDOPA AND LEVODOPA/BENSERAZIDE IN HEALTHY SUBJECTS.

This is a medical-scientific research study. The purpose of the study is to investigate the effect of multiple doses of the study compound BIA 28-6156 on the pharmacokinetics of the drugs levodopa-carbidopa (Group 1) and levodopa-benserazide (Group…