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ID
Source
Brief title
Health condition
Muscle protein metabolism
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary study parameters include myofibrillar protein synthesis rates, expressed as FSR (%/h), using muscle-protein bound L-[ring-13C6]-phenylalanine enrichments and muscle tissue-free and plasma L-[ring-13C6]-phenylalanine enrichments as precursor.
Secondary outcome
Secondary endpoints will be plasma amino acid concentrations (total amino acid profile), glucose, and insulin concentrations.
Study objective
H0= Postprandial muscle protein synthesis rates do not differ between the 2 intervention groups (P>0.05)
H1= Postprandial muscle protein synthesis rates differ between the 2 intervention groups (P<0.05)
Study design
Blood and muscle samples will be collected at regular time intervals (bloodsamples every hour, 3 muscle biopsies during the 5h postprandial period).
Intervention
Subjects will either consume 40 g plantbased or animal protein (isonitrogenous amount) in the form of a ready-to-eat product (n = 12 per group).
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Inclusion criteria
• Males
• Aged between 18 - 35 years
• Healthy, recreationally active (max 3 days per week performing activities)
• BMI 18.5 – 27.5 kg/m2
Exclusion criteria
• Females
• Diagnosed diabetes
• Wheat allergy
• Celiac disease
• Smoking
• Diagnosed metabolic or intestinal disorders
• A history of neuromuscular problems
• Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
• Participation in structured resistance exercise program
• Previous participation in a 13C amino acid tracer study within the last year
Design
Recruitment
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL6224 |
| NTR-old | NTR6380 |
| Other | : METC 163055 |