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The effects of hyperoxia on organ dysfunction and outcome in critically ill patients with SIRS

1. To study the short- and long-term effect of different target PaO2's on circulatory status, organ dysfunction and outcome.2. To study underlying mechanisms of hyperoxia by determining differences in oxidative stress response between the…

Handling oxygenation targets in adults with acute hypoxaemic respiratory failure in the intensive care unit: A randomised clinical trial of a lower versus a higher oxygenation target

To assess the benefits and harms of two targets of partial pressure of oxygen in arterial blood (PaO2) in guiding the oxygen administration in acutely ill adults with hypoxaemic respiratory failure at ICU admission.

Intrauterine resuscitation during term labor by maternal hyper oxygenation: a pilot study.

To investigate the effect of maternal hyperoxygenation with 100% in the second stage of labor and in the presence of abnormal fetal heart rate (FHR) patterns on fetal condition, instrumental delivery rate and free radical production. In case a…

Treatment of Cancer in the Head and Neck:
The Role of Hyperbaric Oxygen in Reducing Swallowing Problems

Primary Study Objectives:This study tries to objectives the potential benefit of prophylactic HBOT in terms of reducing / limiting the amount of dysphagia and / or xerostomia for tumors in the head and neck, specifically originating from the…

The cardiovascular effects of hyperoxia during and after CABG surgery

1. To study the effect of different target PaO2's on myocardial damage, hemodynamics, microcirculation and organ perfusion in CABG patients.2. To study underlying mechanisms of hyperoxia by determining differences in oxidative stress response…

Hyperoxic exercise training as an innovative therapy to improve metabolic control, endothelial dysfunction and physical fitness in deconditioned type 2 diabetes patients

This research project aims to investigate whether hyperoxic interval training improves whole body insulin resistance, endothelial dysfunction, cardiovascular fitness, lipid metabolism and glycemic control in the treatment of deconditioned non-…

Cardiovascular dose-response to supplemental oxygen in healthy volunteers

To explore the dose-response relationship between supplemental oxygen and sublingual microcirculatory perfusion and hemodynamics in healthy volunteers

The effect of inspiratory oxygen fraction on the ratio of partial arterial oxygen pressure and inspiratory oxygen fraction (PaO2/FiO2 ratio) in mechanically ventilated patients with and without mild to moderate ARDS

To study the relation between PaO2/FiO2-ratio and FiO2

Comparing Restrictive vs. Liberal Oxygen Strategies for Trauma Patients: The TRAUMOX2 Trial

The main aim is to compare the effect of a restrictive versus liberal oxygen strategy the first eight hours after trauma on the incidence of 30-day mortality and/or major respiratory complications (pneumonia and ARDS) within 30 days (combined…

The effect of Hyperbaric OxygeN therapy on brEast cancer patients with late radiation toxicitY

To assess whether HBOT reduces pain, and improves physical functioning and QoL in breast cancer patients with late radiation toxicity.

Treatment of Skin Severity in Ichthyosis with Hyperbaric Oxygen Therapy

To assess clinical improvement of skin severity in patients with ichthyosis

Hyperbaric OXygen therapy for ACute Acoustic Trauma

This study has been transitioned to CTIS with ID 2024-517739-35-00 check the CTIS register for the current data. The objective of this study is to investigate whether hyperbaric oxygen therapy twice-daily for five days (HBOT5) is superior to…