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A Double-blind, Randomized, Multicenter Study to Evaluate the Safety and
Efficacy of AMG 145, Compared With Ezetimibe, in Hypercholesterolemic Subjects
Unable to Tolerate an Effective Dose of a HMG-CoA Reductase Inhibitor Due to
Muscle Related Side Effects

Approved WMORecruitment stopped

Primary objective:To evaluate the effect of AMG 145 administered subcutaneously (SC) once every month (QM) compared with ezetimibe (Part B), on percent change from baseline in low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemic…

A Double-blind, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of AMG 145, Compared With Ezetimibe, in Hypercholesterolemic Subjects Unable to Tolerate an Effective Dose of a HMG-CoA Reductase Inhibitor Due to Muscle Related Side Effects

A Double-blind, Randomized, Multicenter Study to Evaluate the Safety and
Efficacy of AMG 145, Compared With Ezetimibe, in Hypercholesterolemic Subjects
Unable to Tolerate an Effective Dose of a HMG-CoA Reductase Inhibitor Due to
Muscle Related Side Effects