Search for a trial

A Phase 1, single-dose, open-label, parallel group study to assess the relative bioavailability of simeprevir, odalasvir and AL-335 when administered in different fixed-dose combination formulations compared to the single agents when administered together, in healthy subjects

Primary Objective•*To evaluate the relative oral bioavailability of SMV, ODV, and AL-335 when administered as different concept fixed-dose combination (FDC) formulations compared to the single agents when administered together, all under fed…

A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SINGLE AND MULTIPLE ASCENDING DOSE STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF RG2459 IN HEALTHY VOLUNTEERS, INCLUDING A SINGLE DOSE PROOF-OF-CONCEPT PART IN PATIENTS INFECTED WITH HEPATITIS C VIRUS, AND A DRUG INTERACTION PART WITH SIMEPREVIR (TMC435) IN HEALTHY VOLUNTEERS

The study will be performed in 4 parts, Parts A, B, C and D. The purpose of the study is to investigate to what extent single doses of RG2459 are tolerated in healthy volunteers and patients with a hepatitis C infection and to what extent multiple…