79 results
This study's first objective is to assess lung mechanics (measured with FOT) in mechanically ventilated infants, in the clinical practice of the NICU, with intermittent measurements during the entire period of mechanical ventilation. The FOT…
Investigate whether, in a routine clinical environment across a number of centers, the fabian-PRICO can adequately maintain oxygen saturation, with minimal staff intervention.
The specific trial aim is to establish whether the use of a high, dynamic 8-12 cmH2O PEEP level strategy to support the lung during stabilisation at birth, compared with a static 5-6 cmH2O PEEP level strategy, increases the rate of survival without…
To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.
The primary objective of this pilot trial is to evaluate if adding mitoPO2 monitoring to standard anaesthetic management enables tissue oxygenation optimisation.
The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…
To compare the effect of umbilical cord clamping after cardiopulmonary stabilisation (Physiological Based Cord Clamping; PBCC) to standard care (Time Based Cord Clamping; TBCC) on intact survival and health care costs in preterm infants.
To survey the clinical and biochemical characteristics of individuals diagnosed with OCTN2, CPT2, CACT or BKT deficiency or suspected with OCTN2 deficiency after NBS in the Netherlands to aid the decision on whether or not to include these disorders…
The overall aim of the study is to gain more insight in as well as understand and map the pharmacokinetics of tacrolimus during pregnancy. Therefore, we will study tacrolimus concentrations in maternal whole blood (routine care) and via area under…
The primary objectives of this study are:- Can EEnG measure colonic motility/activity?- Can EEnG be used to distinguish between healthy subjects and patients suffering from a colonic motility disorder.Secundary objective:- What is the…
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…
To develop a prediction model for BPD using a range of multimodal predictors assessed in the first two weeks of life.
Evaluate the safety and feasibility of providing automated tactile stimulation in response to apnea, bradycardia and/or desaturation using the BreatheBuddy.
We will combine four 7 Tesla MRI markers in extremely preterm infants (MRSI; SWI; PC-MRI; ihMT) to assess (1) if they can predict outcome until 2 years of age; (2) if they are of added value to 3 Tesla prematurity (Kidokoro et al., 2013) and (3) if…
Assess the potential efficay of L-serine dietary supplementation in patients children with a GRIN2B LoS mutation.
To compare the effect of two target ranges (91%-95% and 92%-96%) while on automated oxygen control on the time spent under the target range in preterm infants.
Our proposal builds on 12 years of sustained EU funding, a consortium covering 11 European countries and 27partners (with non-EU sites in African and two Asian populations to provide a global perspective) and our cuttingedge new research, which has…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
The project*s overarching aim is to diminish respiratory disease burden in moderate-late preterm born infants in their first 18 months of life. We have formulated the following specific objectives: 1. Determine whether the introduction of our follow…
Primary objective: To compare the safety of treatment with ELGN-2112 to placebo in preterm infants born less than 26 weeks GA and IUGR infants<3rd percentile * born at 26-32 weeks GA. * According to Fenton preterm growth chart. Secondary…