Search for a trial

A proof of concept study on the effect of tianeptine on opioid-­induced respiratory depression

Here we will perform a proof of concept study on the ability of the antidepressant tianeptine to prevent respiratory depression from the opioid alfentanil in humans.

The effect of intravenous tianeptine on an established model of opioid-induced respiratory depression (OIRD) in healthy volunteers: a population pharmacokinetic and pharmacodynamic study (the Tianeptine study)

To assess whether tianeptine is able to antagonize opioid-induced respiratory depression.