Search for a trial

Efficacy, Safety, and tolerability of GRT6005 in subjects with moderate to severe chronic low back pain

To assess the analgesic efficacy, safety, and tolerability of once daily orally administered GRT6005 in a total of 3 fixed doses (i.e., 200 µg, 400 µg, and 600 µg GRT6005) compared to placebo in subjects with moderate to severe chronic LBP.

A randomized, single center, 2-way crossover, comparator controlled Phase I trial to evaluate the effect of a new analgesic on ventilation in healthy subjects

This trial assesses the safety profile of GRT6005 in terms of its effect on respiratory function. Data on its effect on ventilation in a model of respiratory depression will be obtained and compared to fentanyl (a strong opioid with comparable…