Search for a trial

Effect of Sodium NItroprusside (SNP) on R,S- and S-Ketamine-induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers

The objectives of the study are to assess whether:(1) SNP will reduce the occurrence of psychomimetic side effects during exposure to low-dose ketamine;(2) SNP will reduce the ketamine-induced increase in blood pressure and cardiac output;(3) SNP is…

A randomised, double blind, placebo-controlled cross-over study to investigate the effects of intravenous S(+)-ketamine on functional brain connectivity using fMRI in healthy volunteers.

By means of resting state network measurments using fMRI we hope to gain more knowlegde about the actions (for example as an analgesic) an side effects of S(+)-ketamine on the central nervous system at different doses. Also blood samples will be…

Effect of µ-opioid receptor (MOR) versus N-methyl-D-aspartate receptor (NMDAR) involvement in ketamine and methadone effects in healthy volunteers with special focus on antinociception, sedation, respiratory depression and pupil constriction

This study is therefore aimed at quantifying the relative contribution of the two major receptor systems involved in S(+)-ketamine and methadone induced analgesia and side effects (respiratory depression, sedation, miosis).

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers

1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…

Pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in healthy volunteers

Aims of the study:1) To obtain pharmacokinetic parameters of S(+)-ketamine;2) To study the pharmacodynamic effects of intravenous S(+)-ketamine on experimental pain;

Treatment of Complex Regional Pain Syndrome type I;A randomised, double-blind, placebo-controlled study with multiple rounds of S(+)-ketamine infusions (The Ket Ket Study)

Primary aim:The primary aim of this study is to evaluate the effect of two consecutive infusions of S(+)-ketamine in patients with CRPS-I on pain relief. The design of the study is prospective, randomised, double-blind and placebo-controlled.…

pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in fibromyalgia

To test the hypothesis that ketamine has a modulatory effect on fibromyalgia

Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers * the ORKA trial

We hypothesize that ketamine stimulates breathing and reverses opioid-induced respiratory depression. We will perform a placebo-controlled randomized and double blind study on the effect of increasing doses of S-ketamine on remifentanil-induced…