149 results
The test product supports normal physical growth in healthy term infants
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
The overall aim of this observational prospective study is to evaluate the association between a) the trajectory of cerebral oxygenation, activity and perfusion as evaluated by NIRS, aEEG, Zonare Doppler Ultrasound and Cytocam-IDF during and 24…
This study has been transitioned to CTIS with ID 2024-514073-22-01 check the CTIS register for the current data. To investigate differences in coagulation between (Omniplasma) and FFP in paediatric cardiac patients, who are undergoing cardiac…
This study has been transitioned to CTIS with ID 2024-513041-37-00 check the CTIS register for the current data. Primary objective of this study is to significantly reduce relevant (moderate/severe) parenchymatous brain injury on postoperative MRI…
The main objective of this longitudinal study is to gain insight into the neurodevelopmental trajectories following neonatal critical illness, from the perinatal period to school-age compared to healthy controls. This insight may lead to the…
This study has been transitioned to CTIS with ID 2024-516123-13-00 check the CTIS register for the current data. Part I:Primary Objective: Evaluate the effects of tiratricol on neurodevelopment in young MCT8 deficiency patients, as measured by the…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
The primary objectives of this study are:1. to investigate the association between both conventional and alternative coagulation tests, and hemostatic complications, including bleeding and clotting complications in pediatric ECMO patients2. to…
The primary objectives of the NO GBS study part 1 are to: - determine the clinical characteristics and outcome, and the prevalence of risk factors used by Dutch guidelines for risk assessment in GBS and E. coli meningitis and sepsis cases aged 0-3…
This study has been transitioned to CTIS with ID 2024-514917-36-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Rx-induction: Comparison of the 3 year EFS rate of 2 induction regimens, GPOH and RAPID COJEC, in patients with high-…
Objective: We propose the Amsterdam Infant Microbiome Study (AIMS). The general objective of AIMS is to establish a research infrastructure that allows for explorative research on the development of the microbiome in relation to healthy growth and…
The project*s overarching aim is to diminish respiratory disease burden in moderate-late preterm born infants in their first 18 months of life. We have formulated the following specific objectives: 1. Determine whether the introduction of our follow…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
Assess the potential efficay of L-serine dietary supplementation in patients children with a GRIN2B LoS mutation.
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…
Primary objectives:To demonstrate that diagnostic sensitivity of plasma metanephrines (free and total) is superior to standard evaluation procedures (urinary Dopamine, HVA and VMA) at diagnosis and end-of-induction assessment.Secondary objectives:•…
PrimaryTo characterise the single and multiple dose to steady state pharmacokinetics of IV zanamivirin hospitalised neonates and infants under 6 months of age with influenza infection.SecondaryTo evaluate the safety and tolerability of IV zanamivir…
To evaluate the performance of a *genotype first approach* (WES-based panel analysis) in diagnostics of genetic predisposition in children with cancer or neoplasms, compared to the current *phenotype first approach* (standard of care). In particular…
This study has been transitioned to CTIS with ID 2024-510579-40-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Phase 1 Dose Finding Studies:-To determine the recommended phase II dose (RP2D) of new systemic therapy regimens. *…