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Improving CNS penetration of radiolabeled TKI PET tracers through PgP/BCRP inhibition

The primary objective of this study is to obtain clinical proof of principle that the addition of a PgP/BCRP inhibitor increases CNS concentrations of tyrosine kinase inhibitors by inhibition of drug efflux transporter function in the blood brain…

Pharmacokinetic study of a new formulation of elacridar

To determine the pharmacokinetic properties of a new elacridar formulation