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A randomized, controlled, open-label, parallel-group, multi-center study to compare the effect of Intrathecal Baclofen Therapy (ITB Therapy®) versus Best Medical Treatment (BMT) on spasticity in post-stroke patients after 6 months active treatment

The objective is to determine whether ITB Therapy is more effective than oral anti-spasticity agents in reducing the spasticity.

A Phase I, Randomized, double-blind, placebo-controlled sequential study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ADX71441 after single oral ascending doses, and multiple oral ascending dose following a standard dose escalation schedule, randomized, double-blind for placebo and positive control, in normal healthy volunteers

To evaluate the safety and tolerability of ascending single and multiple oral doses of ADX71441 as compared to placebo in healthy volunteers.To evaluate the pharmacokinetics of orally administered single and multiple doses of ADX71441 and its…

The influence of different flow rates of intrathecal baclofen infusion on dystonia and pain in Complex Regional Pain Syndrome type 1

Primary aim of the study is to compare the efficacy and safety of two flowrates of ITB while maintaining a constant daily dose.