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Intranasal administration of oxytocin in children with Prader-Willi Syndrome. A randomized, open-label, cross-over trial of different treatment regimens of oxytocin administration. Effects on eating behaviour and social behaviour.

To evaluate the effects of long-term intranasal oxytocin on social behaviour in children with PWS and to compare the effects of different doses and frequencies of oxytocin administration

Father Trials: Hormonal Experiments on Prenatal and Postnatal Parenting

In a series of randomized control trials (RCTs) the following hypothesis will be tested: Intranasal administration of oxytocin and vasopressin affect neural and behavioral responses to infant signals and threat to the infant.* Oxytocin and…

Boosting Oxytocin after trauma: Neurobiology and the Development of Stress-related symptoms.

Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…

(Grand)parenting, oxytocin, and the oxytocin receptor gene: an fMRI and observational study

With the proposed study we aim to gain insight into the effects of oxytocin (OT) on both parents* and grandparents* sensitive, empathic, and protective responses to their (grand)children, and in the neural origins of these responses.The primary…

Randomized, double-blind, placebo-controlled oxytocin trial in children with Prader-Willi syndrome.
Effects on social behaviour.

To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.

Attenuating social anxiety: The effect of oxytocin on (inter-)personal space, mimicry, and communication

The main objective of the present protocol is to investigate to what extent oxytocin modulates specific aspects of interpersonal approach, mimicry, and communication in healthy volunteers with varying degrees of social anxiety.Results from this…

Boosting oxytocin after trauma: The effects of intranasal oxytocin administration on emotional and motivational brain processes in PTSD

In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…

SOCIAL-EMOTIONAL BEHAVIOUR IN MALE PSYCHOPATHS AFTER DOUBLE-BLIND PLACEBO-CONTROLLED ADMINISTRATION OF INTRANASAL OXYTOCIN

Fundamental research with the objective to gain more insight in empathic processes within people suffering from psychopathy. Goal is to evaluate if affective empathic can be temporarily altered (in terms of minutes).

Short- and long-term effects of oxytocin on empathy in autistic male adults.

Our study aims at investigating whether male adults with ASD differ from healthy male adults in their neurophysiological responses to positive and negative empathy-evoking pictures when taking oxytocin intranasally once. To this end we will compare…

Effects of oxytocin on approach behavior and social action control

The main objective of the present protocol is to investigate to what extent oxytocin modulates specific aspects of approach behavior and action control in healthy volunteersResults from this study shall give rise to designing a future study on the…

The effects of oxytocin on implicit empathic behavior

To study whether the administration of oxytocin leads to stronger empathic responses on 3 different empathy-related tasks compared to a placebo.

The effect of oxytocin on prosocial behavior in social anxiety disorder

Objective: This study hypothesizes that an oxytocin inhalation will increase prosocial behavior and reduces social anxiety during social interaction specifically in patients with SAD in comparison to a clinical and healthy control group

Caregiving fathers: do hormones help them along?

This proposal centers on hormone-behavior dynamics in paternal caregiving, with the goal of gaining a better understanding of the development of human paternal caregiving. There is limited information on the hormonal basis of caregiving patterns in…

Intranasal administration of oxytocin in children with Prader-Willi Syndrome. A randomized, double-blind, placebo-controlled cross-over trial. Effects on satiety and food intake,
and social behaviour.;Amendment: Six months open-label extension to the original study

To evaluate the effects of intranasal oxytocin compared to placebo administration on appetite, satiety and food intake.Also effects on social behavior, BMI, body composition, IGF-I levels and genetic differences (deletion / mUPD). To assess oxytocin…

Oxytocin, friendship and dealing with emotions

Objectives: 1) To investigate whether attachment security, autonomy-connectedness, and childhood experiences moderate effects of social support during stress; 2) To investigate the influence of oxytocin on the ability to be close to others (in an…

Continued versus discontinued oxytocin stimulation of labour in a double-blind randomised controlled trial

To investigate whether discontinuation of Syntocinon® infusion after the onset of active labour decreases caesarean section rates compared to usual care; continuation of oxytocin until the baby and placenta is born.

The role of dopamine and oxytocin in individual and social performance monitoring

The aim of this study is to improve our understanding of the mechanisms underlying altered social performance monitoring from a pharmacological perspective by directly comparing the effects of dopamine and oxytocin on individual and social…

Combining emotion recognition training with oxytocin administration: A psychobiological approach

The primary aim of this study is to examine the effectiveness of a psychobiological intervention combining oxytocin administration with ERT. We hypothesize that the combined intervention will be more effective in improving emotion recognition skills…

The effect of oxytocin on eye contact and trust: a placebo controlled study

The aim of the study is to understand whether enhanced oxytocin levels lead to increased eye contact between patient and physician, and if this in turn improves the patient-physician relationship as perceived by the patient.

Mild induced labour prior to planned caesarean delivery to improve neonatal outcome - a randomized trial (Lacarus)

The primary outcome is the occurrence of neonatal respiratory morbidity within 24 hours after birth. Painful contractions. Progression of labour after stopping OCT. Nonreassuring fetal heart rate pattern during OCT.