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STUDY TO INVESTIGATE THE EFFECTS OF LEVOCETIRIZINE AND DIPHENHYDRAMINE ON COGNITIVE AND PSYCHOMOTOR FUNCTIONING DURING SIMULATED DIVING AT 2 BAR AND 4 BAR IN PROFESSIONAL NAVY DIVERS

Investigate the effects of levocetirizine, diphenhydramine and placebo on cognitive and psychomotor functioning during controlled simulated diving in a recompression chamber in professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).

Double blind, placebo controlled, randomized study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of oxathridine
after a single oral administration ranging from 0.5 mg to 100 mg in healthy male subjects (part 1) followed by the assessment of the effect of 3 different oxathridine oral doses on polysomnography in comparison to 50 mg diphenhydramine and placebo in healthy male subjects (part 2).

Primary objective: Study Part 1 : Single Ascending Dose: • To determine the clinical and biological safety and tolerability of oxathridine after an oral increasing single dose administration oxathridine in healthy male subjects. Study Part 2 : Proof…

A double-blind, randomized, placebo-controlled, five-way cross-over interaction trial to investigate the inhibitory effect of olanzapine on a THC-induced increase on the Positive and Negative Syndrome Scale

- To investigate whether olanzapine influences the (psychomimetic) effects of THC, in particular on the Positive and Negative Syndrome Scale (PANSS) - To further explore the pharmacologic basis of the THC model - To investigate the effects of…

Evaluation of the cognitive and psychomotor effects of LY2624803 following bedtime dosing in healthy subjects

This study is being performed to evaluate the cognitive and psychomotor effects of the new compound LY2624803 after bedtime dosing.

An Exploratory Multicenter, Double-Blind, Diphenhydramine- and Placebo-Controlled Safety, Efficacy and Biomarker Study with JNJ-42847922 in Subjects with Major Depressive Disorder.

Primary Objective:To investigate the safety and tolerability of JNJ-42847922 in subjects with MDD. Study medication will be administered for 10 days in women of childbearing potential (WOCBP) or for 4 weeks in all other subjects.Secondary Objectives…