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Biodistribution and dosimetry of the newly developed P-gp PET tracer [11C]laniquidar in healthy volunteers

(1) To assess biodistribution of [11C]laniquidar in healthy volunteers; (2) To determine the actual effective radiation dose of [11C]laniquidar in humans; (3) To assess the metabolic profile of [11C]laniquidar in humans.

Test-retest of the newly developed P-gp PET tracer [11C]laniquidar in healthy volunteers

(1) To assess [11C]laniquidar plasma and brain kinetics in healthy volunteer(s), including assessment of the presence of radioactive metabolites in plasma. (2) To develop a tracer kinetic model for [11C]laniquidar in humans. (3) To determine intra-…