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Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis: An age and sex-matched controlled Study.

The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…

Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia

W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia

Gadobutrol (Gadovist®) versus gadofosveset-trisodium (Vasovist®) in MR venography of the peripheral venous vasculature in deep vein thrombosis: is their a need for blood pool contrast agents?

Primary objectives:1. To determine image quality and diagnostic accuracy of CE-MRV using a new, optimized high resolution 3D T1 weighted volume interpolated gradient echo sequence with fat suppression (THRIVE) with both a blood pool and a…

INTERVENTIONAL MANAGEMENT OF STROKE TRIAL CLINICAL PROTOCOL - IMS III
A phase III, randomized, multi-center, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (Activase®/Actilyse®) alone when initiated within three hours of acute ischemic stroke onset.

The primary objective of the trial is to determine if ischemic stroke subjects with a baseline NIH Stroke Scale Score (NIHSSS] >= 10 (8-9 with positive CTA) treated with recombinant tissue plasminogen activator (rt-PA; [Alteplase recombinant…

Evaluation of the Vascutek Ltd. Thoracic Endovascular Stent Graft System (Thoraflex) in the Treatment of Aneurysm or Penetrating Ulcer of the Descending Thoracic Aorta

The purpose of this study is to investigate the clinical performance of Thoraflex in the treatment of subjects with aneurysm or penetrating ulcer of the descending thoracic aorta.The primary objective of this study is to demonstrate the safety and…

Influence of changes in brain activity during movement observation and execution on the recovery of motor function after stroke.

The objective of the study is to examine the relation between changes in cortical activity during movement observation and execution, and changes in motor function and motor control after stroke. The hypotheses to study this objective are: 1. Brain…

MR Imaging of cerebral blood flow and autoregulation in patients with steno-occlusive vertebro-basilar artery disease.

The primary objective will be to assess whether cerebrovascular reactivity is impaired in patients with steno-occlusive disease of the vertebrobasilar artery .

Study to investigate the sensitivity and specificity of 3.0 Tesla MRI, MRS and ultrasound imaging for carotid artery plaque dimension and composition assessment.

PrimaryTo investigate sensitivity and specificity of 3.0 Tesla MRI and MRS for dimension and composition assessment of carotid artery plaques, in particularly those plaques with lipid rich necrotic cores (LRNC), with the aim to develop these…

ACURATE TA* Transapical Aortic Bioprosthesis for Implantation in Patients with Severe Aortic Stenosis

Primary: To evaluate the safety of the study device in patients presenting with severe aortic stenosis (AS) considered to be high risk for surgery.Secondary: To evaluate adverse events and study device performance.

Critical Limb Ischemia: MRA And CTA Study (Feasibility)

The main objective of this pilot study is to evaluate the burden of an additional CTA and MRA procedure in patients, and to evaluate the quality of the CTA and MRA protocols.

Creatine kinase and blood pressure response

In this study, we will prospectively assess the association between serum CK and response to standard antihypertensive drugs (calcium blockers or monotherapy with other antihypertensive drugs according to the policy of the general practitioner).

Treatment of resistant hypertension using a radiofrequency percutaneous transluminal angioplasty Catheter (POST MARKET APPROVAL SURVEILLANCE STUDY)

Aim of the study is to study a new therapeutic option for the treatment of hypertension

Cost-effectiveness of a lifestyle intervention on health and sustainable employability among workers of 40 years and older with high physical work demands: a randomized controlled trial

- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.

IMPella versus IABP REduces mortality in STEMI patients treated with primary PCI IN SEVERE and deep cardiogenic SHOCK.
An international multicenter, randomized trial of the Impella cVAD (left ventricular assist) device versus Intra Aortic Balloon Counter Pulsation (IABP) therapy for acute ST-elevation myocardial infarction patients treated with primary PCI in severe and deep cardiogenic shock

The primary objective of this study is to determine whether the Impella cVAD device vs. IABP therapy leads to a higher 30 day survival rate in shock STEMI patients in the setting of primary PCI.

Protocol I1V-MC-EIAN Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition with Evacetrapib in Patients at a High-Risk for Vascular Outcomes - the ACCELERATE Study

The primary objective of this study is to test the hypothesis that evacetrapib 130 mg daily, in comparison to placebo, reduces the incidence of the composite endpoint of cardiovascular (CV) death, myocardial infarction (MI), stroke, coronary…

IOinated contrast DILution in digital subtraction angiography of the limb:
a randomized controlled trial with three different concentrations of iodine

To compare the confidence of the interventional radiologist in diagnosing and treating arterial stenoses and occlusions by digital subtraction angiography with contrast concentrations of 300, 240 and 140 mg iodine per ml. Also, we will compare the…

Aldosterone-induced microvascular dysfunction as a cause of salt-sensitivity in obesity?

To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…

A prospective open-label non-randomized pivotal study to evaluate the safety and performance of
the Horizon* Abdominal Aortic Aneurysm (AAA) Stent graft System.

The primary objectives of the study are to evaluate the safety and performance of the Horizon* AAA Stent Graft System.

Effect of Tocilizumab on subclinical arterial inflammation and stiffness in patients with active rheumatoid arthritis (DAS28 > 3.2)

To investigate the effect of anti-IL6 therapy with tocilizumab on subclinical arterial inflammation (endothelial dysfunction) and stiffness in patients with treatment resistant rheumatoid arthritis at baseline and after 6 months treatment

TELEHYPE TELEmonitoring and self-management of uncontrolled HYPErtension

To assess the one-year (cost)effectiveness of telemonitoring of blood pressure and self-management support via an internet-based service in addition to usual care as compared to usual care alone in a pragmatic trial in patients with uncontrolled…