W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia
ID
Source
Brief title
Condition
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
HPV
Secondary outcome
cardiac parameters
hypoxic ventilatory response
Background summary
During hypoxia, a phenomenon called hypoxic pulmonary vasoconstriction, occurs.
This reaction protects the body by lowering bloodflow to less ventilated parts
of the long. This protecting mechanism can also harm the patient. This is the
case with COPD and the development of pulmonary hypertension. The ryanodine
receptor plays an important role in HPV. MH patients have a mutation in the
ryanodine receptor gen and studies in mice show a different reaction to
hypoxia.
Study objective
W want to investigate the influence of a mutaion in the MH allel on the HPV and
the normal reaction of MH patients to hypoxia
Study design
case controlled intervention study
Intervention
hypoxia
Study burden and risks
headache during hypoxia somethimes occurs, which is treated with paracetamol
a bruise may occur on the spot of the iv
albinusdreef 2
2333 ZA, Leiden
NL
albinusdreef 2
2333 ZA, Leiden
NL
Listed location countries
Age
Inclusion criteria
Healthy Malignant Hyperthermia patients with a phenotypic high susceptibility and a proven causative mutation.
The major inclusion criteria are that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.
Exclusion criteria
• Obesity (BMI > 30)
• Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes
• Presence of psychiatric disease
• History of chronic alcohol or drug use
• Possibility of pregnancy
• Lactation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35083.058.11 |